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. 2020;37(4):e2020012.
doi: 10.36141/svdld.v37i4.9966. Epub 2020 Dec 16.

Predictive value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with hypersensitivity pneumonia

Fatma Üçsular  1 , Gülru Polat  1 , Gülistan Karadeniz  1 , Aysu Ayranci  1 , Merve Keskin  1 , Melih Buyukşirin  1 , Filiz Güldaval  1 , Enver Yalniz  1
Affiliations

Predictive value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with hypersensitivity pneumonia

Fatma Üçsular et al. Sarcoidosis Vasc Diffuse Lung Dis. 2020.

Abstract

Aim: To evaluate Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) in patients with HP.

Method: A sample of 140 total patients, 50 having chronic HP and 20 having acute HP, and a control group of 70 more patients were included in this retrospective study conducted with hospital Ethical Committee approval.

Results: PLR and NLR values were significantly higher in all HP patients than in the control group ( p <0.001). In addition, these biomarkers were significantly higher in patients with acute HP than in the chronic HP group (p = 0.017 and p = 0.044, respectively). The cutoff values for PLR and NLR were: (1) 177 (p = 0.020) and 2.76 (p <0.0001) between the HP patients and the control group, and, (2) 110 (p = 0.0054) and 2.15 (p = 0.03), between the acute and chronic HP groups.

Conclusion: PLR and NLR values are inexpensive and easy parameters that can guide in diagnosing hypersensitivity pneumonia in combination with clinical, radiological and pathology findings.and the acute-chronic differentiation of the disease. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (4): e2020012).

Keywords: acute/chronic hypersensitivity pneumonia; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio.

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Figures

Fig. 1.
Fig. 1.
ROC analysis for PLR / NLR values of all patients with hypersensitivity pneumonia and the control group.
Fig. 2.
Fig. 2.
ROC analysis for PLR and NLR values in patients with chronic and acute HP
See this image and copyright information in PMC

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