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. 2020 Sep;16(3):294-299.
doi: 10.5114/aic.2020.99264. Epub 2020 Oct 2.

Endocan expression correlated with total volume of coronary artery dilation in patients with coronary artery ectasia

Iwańczyk Sylwia  1 , Aleksander Araszkiewicz  1 , Michał Borger  1 , Mikołaj Kamiński  1 , Michał Wrotyński  1 , Ewa Chmara  1 , Artur Cieślewicz  1 , Artur Radziemski  1 , Maciej Lesiak  1
Affiliations

Endocan expression correlated with total volume of coronary artery dilation in patients with coronary artery ectasia

Iwańczyk Sylwia et al. Postepy Kardiol Interwencyjnej. 2020 Sep.

Abstract

Introduction: Inflammation and angiogenesis disturbances are considered as factors contributing to the development of coronary artery ectasias (CAE). Endocan (endothelial cell-specific molecule-1 - ESM-1) regulates both inflammatory and angiogenetic processes. However, there are no data about the correlation between endocan level and the severity of CAE measured with total volume of coronary artery dilation.

Aim: To assess whether the severity of the inflammatory process measured as endocan concentration correlates with the total volume of CAE.

Material and methods: We selected prospectively a total of 43 consecutive patients with coronary artery ectasia from 2240 patients who underwent coronary angiography in our center. Determination of endocan was performed by using the Human Endothelial cell-specific Molecule 1 (ECSM1/ENDOCAN) ELISA Kit. 3D QCA (three-dimensional quantitative coronary angiography) was used for coronary lesion and aneurysm quantification. The total volume of dilation was defined as the volume of all aneurysms and ectasias of coronary arteries in 1 patient.

Results: The mean volume of all aneurysms in 1 patient was 677 ±878.7 mm3. The total aneurysm volume was positively strongly correlated with endocan concentration (Pearson correlation coefficient: 0.811; 2-tailed p < 0.001).

Conclusions: Endocan is a potential marker of vascular wall damage mainly as a result of inflammation in the course of atherosclerosis, but also vascular remodeling as a result of a disturbance of pro- and anti-angiogenic processes. Endocan level reflects the intensity of the above processes and therefore correlates with the severity of CAE, measured as the total volume of dilation.

Keywords: angiogenic proteins; coronary aneurysms; coronary atherosclerosis; inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
3D reconstruction (C) based on 2D angiographic projections (A and B). The red line in image A and B is the common image point and determines the point of maximum short and long diameter. The green lines mark the boundaries of the aneurysm
Figure 2
Figure 2
Linear regression correlation between endocan level and total aneurysm volume
See this image and copyright information in PMC

References

    1. Swaye PS, Fisher LD, Litwin P, et al. . Aneurysmal coronary artery disease. Circulation 1983; 67: 134-8. - PubMed
    1. Araszkiewicz A, Grygier M, Lesiak M, et al. . Review article From positive remodelling to coronary artery ectasia. Is coronary artery aneurysm a benign form of coronary disease? Kardiol Pol (Pol Heart J) 2009 ; 67: 1390-5. - PubMed
    1. Leschka S, Alkadhi H, Plass A, et al. . Accuracy of MSCT coronary angiography with 64-slice technology: first experience. Eur Heart J 2005; 26: 1482-7. - PubMed
    1. Greil GF, Stuber M, Botnar RM, et al. . Coronary magnetic resonance angiography in adolescents and young adults with Kawasaki disease. Circulation 2002; 105: 908-11. - PubMed
    1. Mavrogeni S, Papadopoulos G, Douskou M, et al. . Magnetic resonance angiography is equivalent to X-ray coronary angiography for the evaluation of coronary arteries in Kawasaki disease. J Am Coll Cardiol 2004; 43: 649-52. - PubMed