Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 1:10:608836.
doi: 10.3389/fonc.2020.608836. eCollection 2020.

Hemicolectomy Does Not Provide Survival Benefit for Right-Sided Mucinous Colon Adenocarcinoma

Jia Huang  1   2 , Qiulin Huang  3 , Rong Tang  3 , Guodong Chen  4 , Yiwei Zhang  4 , Rongfang He  5 , Xuyu Zu  1   2 , Kai Fu  6 , Xiuda Peng  7 , Shuai Xiao  1   3
Affiliations

Hemicolectomy Does Not Provide Survival Benefit for Right-Sided Mucinous Colon Adenocarcinoma

Jia Huang et al. Front Oncol. .

Abstract

Background: The extent of bowel resection is widely debated in colon cancer surgery. Right hemicolectomy (RHC) and partial colectomy (PC) are the most common operation options for right-sided colon cancer (RCC). However, there are still no treatment guidelines or published studies to guide surgical options for mucinous adenocarcinoma (MAC) of RCC.

Methods: Patients with MAC and non-specific adenocarcinoma (AC) of RCC who underwent RHC and PC from 2010 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The general characteristics and survival were compared and analyzed.

Results: A total of 27,910 RCC patients were enrolled in this study, among them 3,413 were MAC. The results showed that race, carcinoembryonic antigen (CEA) level, perineural invasion (PNI), tumor size, tumor location, TNM stage, liver metastasis, chemotherapy were significantly different between MAC and AC groups. The MAC group had similar dissected lymph nodes, but more positive lymph nodes than the AC group. The overall survival (OS) of the MAC group was poorer than that of the AC group, but cancer-specific survival (CSS) was similar between the two groups. The RHC subgroup of the MAC group had more patients of age ≤60 years, larger tumor size, cecum/ascending colon location and dissected lymph nodes than the PC subgroup, but similar positive lymph nodes, perioperative mortality, OS and CSS as the PC subgroup. Moreover, the univariate and multivariable analyses for the survival of RCC patients with MAC showed that RHC might not be a superior predictor for OS and CSS compared with PC.

Conclusions: RHC could not dissect more positive lymph nodes or provide long-term survival benefits for RCC patients with MAC compared with PC. This study could provide some evidence for surgery treatment selection for MAC of RCC, which has important clinical value in individual management of colon cancer patients.

Keywords: mucinous adenocarcinoma; partial colectomy; right hemicolectomy; right-sided colon cancer; survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Patient selection flowchart.
Figure 2
Figure 2
Long-term survival of RCC according to histopathology type. (A, B) The survival curves showed that the MAC of RCC group had worse OS (A) but similar CSS (B) with the AC of RCC group. RCC, right-sided colon carcinoma; OS, overall survival; CSS, cancer-specific survival; MAC, mucinous adenocarcinoma; AC, non-specific adenocarcinoma.
Figure 3
Figure 3
Long-term survival of MAC of RCC according to surgery options. (A, B) The stratified analysis survival curves showed that the MAC of RCC group who underwent PC had comparable OS (A) and CSS (B) with the AC of RCC group; (C, D) The stratified analysis survival curves showed that the MAC of RCC group who underwent the RHC had worse OS (C) but similar CSS (D) with the AC of RCC group. (E, F) The survival curves showed that the MAC of RCC patients in the RHC group had similar OS (E) and CSS (F) as the PC group. PC, partial colectomy; RHC, right hemicolectomy.
Figure 4
Figure 4
The sub-hierarchy analyses for long-term survival of MAC of RCC according to independent risk factors. (A, B) The survival curves showed that the MAC of RCC patients in the RHC group had similar OS and CSS as the PC group when sub-stratified by age (A, B), CEA level (C, D), PNI (E, F), differentiation (G, H) and TNM stage (I–L).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin (2018) 68(6):394–424. 10.3322/caac.21492 - DOI - PubMed
    1. Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, et al. NCCN Guidelines Insights: Colon Cancer, Version 2.2018. J Natl Compr Canc Netw (2018) 16(4):359–69. 10.6004/jnccn.2018.0021 - DOI - PMC - PubMed
    1. Grothey A, Venook AP. Optimizing Adjuvant Therapy for Localized Colon Cancer and Treatment Selection in Advanced Colorectal Cancer. J Natl Compr Canc Netw (2018) 16(5s):611–5. 10.6004/jnccn.2018.0038 - DOI - PubMed
    1. Blakely AM, Lafaro KJ, Eng OS, Ituarte PHG, Fakih M, Lee B, et al. The Association of Tumor Laterality and Survival After Cytoreduction for Colorectal Carcinomatosis. J Surg Res (2020) 248:20–7. 10.1016/j.jss.2019.10.001 - DOI - PubMed
    1. Benedix F, Schmidt U, Mroczkowski P, Gastinger I, Lippert H, Kube R. Colon carcinoma–classification into right and left sided cancer or according to colonic subsite?–Analysis of 29,568 patients. Eur J Surg Oncol (2011) 37(2):134–9. 10.1016/j.ejso.2010.12.004 - DOI - PubMed

LinkOut - more resources