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. 2021 Aug;268(8):2821-2830.
doi: 10.1007/s00415-021-10430-y. Epub 2021 Feb 17.

Long term follow-up in advanced Parkinson's disease treated with DBS of the subthalamic nucleus

Maria Antonietta Volonté  1 , Giacomo Clarizio  1 , Sebastiano Galantucci  1 , Pietro Giuseppe Scamarcia  1 , Rosalinda Cardamone  1 , Lina Raffaella Barzaghi  2 , Monica Falautano  1 , Pietro Mortini  2 , Giancarlo Comi  3 , Massimo Filippi  4   5   6   7   8
Affiliations

Long term follow-up in advanced Parkinson's disease treated with DBS of the subthalamic nucleus

Maria Antonietta Volonté et al. J Neurol. 2021 Aug.

Abstract

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting both motor and non-motor systems. Deep brain stimulation of the subthalamic nucleus (STN-DBS) has been an approved treatment for PD for more than 30 years, but few data are available regarding its long-term effectiveness.

Objective: The aim of this study is to evaluate patients' outcome, both from a motor and non-motor perspective, 9 to 14 years after DBS implantation. We have investigated patients with advanced PD and treated with STN-DBS, in relation to key clinical features of PD.

Methods: 18 patients were assessed both retrospectively and prospectively. They underwent motor examination, neuropsychological evaluation and questionnaires on the quality of life, preoperatively, as well as 1, 9 and 14 years after DBS surgery. All patients were implanted with STN-DBS at San Raffaele Hospital between 2004 and 2010.

Results: 13 males and five females underwent DBS implantation with a mean PD duration of 11 years. Stimulation significantly improved med-off/stim-on condition up to 9 years, compared to the preoperative off state, and med-on/stim-on condition at 14 years, compared to med-on/stim-off state. Long term improvement specifically involved tremor and rigidity, as well as dopaminergic daily dose. At the same time, STN-DBS had no long-lasting effect on axial symptoms and cognitive functions.

Conclusions: STN-DBS remains an effective therapy for advanced PD, also over the years. Despite the underlying progression of the disease, this treatment extends the period in which the overall quality of life is still acceptable.

Keywords: Deep brain stimulation; Follow-up studies; Parkinson’s disease; Subthalamic nucleus.

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References

    1. Romito LM, Contarino MF, Vanacore N, Bentivoglio AR, Scerrati M, Albanese A (2009) Replacement of dopaminergic medication with subthalamic nucleus stimulation in Parkinson’s disease: long-term observation. Mov Disord 24:555–561. https://doi.org/10.1002/mds.22390 - DOI
    1. Witt K, Daniels C, Reiff J, Krack P, Volkmann J, Pinsker MO, Krause M, Tronnier V, Kloss M, Schnitzler A, Wojtecki L, Bötzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G (2008) Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson’s disease: a randomised, multicentre study. Lancet Neurol 7:605–614. https://doi.org/10.1016/S1474-4422(08)70114-5 - DOI - PubMed
    1. Miocinovic S, Somayajula S, Chitnis S, Vitek JL (2013) History, applications, and mechanisms of deep brain stimulation. JAMA Neurol 70:163. https://doi.org/10.1001/2013.jamaneurol.45 - DOI - PubMed
    1. Castrioto A, Lozano AM, Poon Y-Y, Lang AE, Fallis M, Moro E (2011) Ten-year outcome of subthalamic stimulation in parkinson disease. Arch Neurol 68:1550. https://doi.org/10.1001/archneurol.2011.182 - DOI - PubMed
    1. Rizzone MG, Fasano A, Daniele A, Zibetti M, Merola A, Rizzi L, Piano C, Piccininni C, Romito LM, Lopiano L, Albanese A (2014) Long-term outcome of subthalamic nucleus DBS in Parkinson’s disease: From the advanced phase towards the late stage of the disease? Parkinsonism Related Dis 20:376–381. https://doi.org/10.1016/j.parkreldis.2014.01.012 - DOI

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