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. 2021 Apr;166(4):1197-1201.
doi: 10.1007/s00705-021-04995-2. Epub 2021 Feb 17.

Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China

Fan Yang  1 , Yixin Xiao  1 , Fumin Liu  1 , Hangping Yao  1 , Nanping Wu  1 , Haibo Wu  2
Affiliations

Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China

Fan Yang et al. Arch Virol. 2021 Apr.

Abstract

Waterfowl are considered to be the natural hosts of avian influenza virus. In 2017, two reassortant highly pathogenic H5N6 avian influenza viruses of clade 2.3.4.4, subclade II, were identified in wild birds in eastern China. Genome sequencing and phylogenetic and antigenicity analysis showed that the viruses originated from multiple reassortments. To evaluate their pathogenicity in mammals, 15 BALB/c mice were infected with these viruses, and survival and weight loss were monitored for 14 days. Infection was associated with moderate pathogenicity in the mice, and the viruses could replicate in the lungs without prior adaptation. Thus, the existence of these viruses poses a continuous threat to both birds and humans.

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References

    1. Wu H, Lu R, Peng X, Xu L, Cheng L, Lu X, Jin C, Xie T, Yao H, Wu N (2015) Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China. Infect Genet Evol 31:64–67. https://doi.org/10.1016/j.meegid.2015.01.019 - DOI - PubMed
    1. Lee EK, Song BM, Lee YN, Heo GB, Bae YC, Joh SJ, Park SC, Choi KS, Lee HJ, Jang I, Kang MS, Jeong OM, Choi BK, Lee SM, Jeong SC, Park BK, Lee HS, Lee YJ (2017) Multiple novel H5N6 highly pathogenic avian influenza viruses, South Korea, 2016. Infect Genet Evol 51:21–23. https://doi.org/10.1016/j.meegid.2017.03.005 - DOI - PubMed
    1. Yang ZF, Mok CK, Peiris JS, Zhong NS (2015) Human Infection with a Novel Avian Influenza A(H5N6) Virus. N Engl J Med 373(5):487–489. https://doi.org/10.1056/NEJMc1502983 - DOI - PubMed
    1. Wong FY, Phommachanh P, Kalpravidh W, Chanthavisouk C, Gilbert J, Bingham J, Davies KR, Cooke J, Eagles D, Phiphakhavong S, Shan S, Stevens V, Williams DT, Bounma P, Khambounheuang B, Morrissy C, Douangngeun B, Morzaria S (2015) Reassortant highly pathogenic influenza A(H5N6) virus in Laos. Emerg Infect Dis 21(3):511–516. https://doi.org/10.3201/eid2103.141488 - DOI - PubMed - PMC
    1. Wu HB, Peng XM, Peng XR, Cheng LF, Lu XY, Jin CZ, Xie TS, Yao HP, Wu NP (2015) Genetic and molecular characterization of H9N2 and H5 avian influenza viruses from live poultry markets in Zhejiang Province, eastern China. Sci Rep UK 5:17508. https://doi.org/10.1038/srep17508 - DOI

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