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. 2022 Apr;28(3):771-776.
doi: 10.1111/odi.13806. Epub 2021 Mar 1.

FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study

Tomasz Olszowski  1 , Marta Milona  1 , Joanna Janiszewska-Olszowska  2 , Krzysztof Safranow  3 , Izabela Uzar  4 , Alicja Walczak  1 , Maciej Sikora  3   5 , Dariusz Chlubek  3 , Grażyna Adler  6
Affiliations

FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study

Tomasz Olszowski et al. Oral Dis. 2022 Apr.

Abstract

Objective: To examine the association of four FCN1 SNPs: -542G>A (rs10120023), -144C>A (rs10117466), +6658C>T (rs148649884), and +7895A>G (rs150625869) with dental caries in Polish children.

Subjects and methods: The study group consisted of 261 15-year-old Polish teenagers: 82 children with "higher" caries experience (having Decayed Missing Filled Teeth, DMFT >5) and 179 children with "lower" caries experience (having DMFT ≤5). Moreover, in additional comparison, a group of 229 children with caries experience (DMFT ≥1) was compared to a caries-free (DMFT =0) group of 32 children. Extraction of genomic DNA was performed from buccal swabs, and genotyping was performed by Real-Time PCR.

Results: FCN1 SNPs +6658C>T and +7895A>G appeared to be monomorphic in our sample. The genotype, allele, or haplotype distributions in FCN1 SNPs -542G>A and -144C>A in children with "higher" caries experience did not differ significantly from those in "lower" caries experience group. Similar results with no significant differences were demonstrated for subjects with DMFT ≥1 compared to subjects with DMFT =0.

Conclusion: FCN1 SNPs are not the markers of dental caries susceptibility in Polish children.

Keywords: children; dental caries experience; ficolin-1; single nucleotide polymorphisms.

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