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Editorial
. 2021 Feb 19;128(4):471-473.
doi: 10.1161/CIRCRESAHA.121.318742. Epub 2021 Feb 18.

Stress Seats a New Guest at the Table of PLN/SERCA and Their Partners

Alicia Mattiazzi  1 , Jil C Tardiff  2 , Evangelia G Kranias  3
Affiliations
Editorial

Stress Seats a New Guest at the Table of PLN/SERCA and Their Partners

Alicia Mattiazzi et al. Circ Res. .
No abstract available

Keywords: Editorials; atrial fibrillation; phospholamban; phosphorylation; sarcoplasmic reticulum.

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Conflict of interest statement

Conflict of Interest

None

Figures

Figure
Figure. Possible effects of increasing SR Ca-uptake on SR Ca- leak.
A. Balance between SR Ca-uptake and leak. The augmented cytosolic Ca buffering produced by the enhanced SR Ca-uptake prevails over the increased SR Ca-leak elicited by the enlarged SR Ca-content. B. Imbalance between SR Ca-uptake and leak. When the increase in SR Ca-uptake is associated with enhanced RyR2 sensitization, the improved SR Ca-uptake may fail to counteract the arrhythmogenic effects of a continuous increase in SR Ca-leak during the decline phase of the Ca transient and diastole.
See this image and copyright information in PMC

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References

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