Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial

Jae-Sung Lim¹, Sun U Kwon², Kyung-Ho Yu¹, Sungwook Yu³, Jong-Ho Park⁴, Byung-Chul Lee¹, Mi Sun Oh¹, Yong-Jae Kim⁵, Joung-Ho Rha⁶, Yang-Ha Hwang⁷, Ji Sung Lee⁸, Sung Hyuk Heo⁹, Seong Hwan Ahn¹⁰, Woo-Keun Seo¹¹, Jong-Moo Park¹², Ju-Hun Lee¹³, Jee-Hyun Kwon¹⁴, Sung-Il Sohn¹⁵, Jin-Man Jung¹⁶, Hahn Young Kim¹⁷, Eung-Gyu Kim¹⁸, Jae-Kwan Cha¹⁹, Man-Seok Park²⁰, Hyo Suk Nam²¹, Hee-Joon Bae²², Dong-Eog Kim²³, Jaeseol Park¹, Yeonwook Kang²⁴, Jimi Choi²⁵, Juneyoung Lee^{25

26}

Affiliations

¹ Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang, Korea.
² Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
³ Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
⁴ Department of Neurology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
⁵ Department of Neurology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁶ Department of Neurology, Inha University Hospital, Incheon, Korea.
⁷ Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
⁸ Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
⁹ Department of Neurology, Kyung Hee University Medical Center, Seoul, Korea.
¹⁰ Department of Neurology, Chosun University Hospital, Gwangju, Korea.
¹¹ Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
¹² Department of Neurology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.
¹³ Department of Neurology, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
¹⁴ Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
¹⁵ Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
¹⁶ Department of Neurology, Korea University Ansan Hospital, Ansan, Korea.
¹⁷ Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.
¹⁸ Department of Neurology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
¹⁹ Department of Neurology, Dong-A University Hospital, Busan, Korea.
²⁰ Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
²¹ Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
²² Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
²³ Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea.
²⁴ Department of Psychology, Hallym University, Chuncheon, Korea.
²⁵ Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
²⁶ BK21 FOUR R&E Center for Learning Health Systems, Korea University, Seoul, Korea.

PMID: 33600710
PMCID: PMC7900397
DOI: 10.5853/jos.2020.03650

Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial

Jae-Sung Lim et al. J Stroke. 2021 Jan.

. 2021 Jan;23(1):128-131.

doi: 10.5853/jos.2020.03650. Epub 2021 Jan 31.

Authors

Affiliations

¹ Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang, Korea.
² Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
³ Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
⁴ Department of Neurology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
⁵ Department of Neurology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁶ Department of Neurology, Inha University Hospital, Incheon, Korea.
⁷ Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
⁸ Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
⁹ Department of Neurology, Kyung Hee University Medical Center, Seoul, Korea.
¹⁰ Department of Neurology, Chosun University Hospital, Gwangju, Korea.
¹¹ Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
¹² Department of Neurology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.
¹³ Department of Neurology, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
¹⁴ Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
¹⁵ Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
¹⁶ Department of Neurology, Korea University Ansan Hospital, Ansan, Korea.
¹⁷ Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.
¹⁸ Department of Neurology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
¹⁹ Department of Neurology, Dong-A University Hospital, Busan, Korea.
²⁰ Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
²¹ Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
²² Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
²³ Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea.
²⁴ Department of Psychology, Hallym University, Chuncheon, Korea.
²⁵ Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
²⁶ BK21 FOUR R&E Center for Learning Health Systems, Korea University, Seoul, Korea.

PMID: 33600710
PMCID: PMC7900397
DOI: 10.5853/jos.2020.03650

No abstract available

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Figures

**Figure 1.**
Mean changes in cognitive scores from baseline to each follow-up in (A, B) cilostazol vs. aspirin and (C, D) probucol vs. no probucol groups. (A, C) Mini-Mental State Examination (MMSE) and (B, D) Montreal Cognitive Assessment (MoCA).

See this image and copyright information in PMC

References

1. Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008;7:875–884. - PMC - PubMed
1. Pearce LA, McClure LA, Anderson DC, Jacova C, Sharma M, Hart RG, et al. Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Lancet Neurol. 2014;13:1177–1185. - PMC - PubMed
1. Ihara M, Nishino M, Taguchi A, Yamamoto Y, Hattori Y, Saito S, et al. Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study. PLoS One. 2014;9:e89516. - PMC - PubMed
1. Park SH, Kim JH, Bae SS, Hong KW, Lee DS, Leem JY, et al. Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation. Biochem Biophys Res Commun. 2011;408:602–608. - PubMed
1. Santos DB, Peres KC, Ribeiro RP, Colle D, dos Santos AA, Moreira EL, et al. Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice. Exp Neurol. 2012;233:767–775. - PubMed

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Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial

Affiliations

Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial

Authors

Affiliations

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources

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