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. 2021 May 1;203(9):1191-1196.
doi: 10.1164/rccm.202101-0142LE.

ACE2 Elevation in Severe COVID-19

Roman Reindl-Schwaighofer  1 , Sebastian Hödlmoser  1 , Farsad Eskandary  1 , Marko Poglitsch  2 , Diana Bonderman  3 , Robert Strassl  1 , Judith H Aberle  1 , Rainer Oberbauer  1 , Alexander Zoufaly  3 , Manfred Hecking  1
Affiliations

ACE2 Elevation in Severe COVID-19

Roman Reindl-Schwaighofer et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Systemic ACE2 (angiotensin-converting enzyme 2) concentration in coronavirus disease (COVID-19) over time stratified by severity of disease. ACE2 increased in patients with severe COVID-19, peaking during the Day 9–Day 11 time interval after hospitalization. On Day 10 of follow-up, 29 of all 32 patients with severe COVID-19 were still alive, and the respective renin–angiotensin system (RAS) data were included in RAS profile analysis, reducing a potential bias introduced by the overall high mortality rate in severe COVID-19 that could impact ACE2 and RAS metabolite trajectories. Continuous lines represent local regression curves with 95% local confidence intervals, whereas dashed lines represent individual patient-level data, with blue and red lines for nonsevere and severe COVID-19, respectively. Numbers at the bottom indicate number of patients available for analysis at each time point. ACE2 concentration is reported in ng/ml.
See this image and copyright information in PMC

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