Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr;31(4):379-380.
doi: 10.1038/s41422-020-00461-x.

TDP-43 triggers immune response via mitochondrial DNA release

Sunny Kumar  1 , Jean-Pierre Julien  2
Affiliations
Comment

TDP-43 triggers immune response via mitochondrial DNA release

Sunny Kumar et al. Cell Res. 2021 Apr.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Excess levels of cytoplasmic TDP-43 lead to mitochondrial penetration of TDP-43 which may trigger mtDNA release with ensuing activation of the cGAS/STING immune sensor.
Activation of this pathway induces pathogenic NF-κB and IFN signaling.
See this image and copyright information in PMC

Comment on

  • TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
    Yu CH, Davidson S, Harapas CR, Hilton JB, Mlodzianoski MJ, Laohamonthonkul P, Louis C, Low RRJ, Moecking J, De Nardo D, Balka KR, Calleja DJ, Moghaddas F, Ni E, McLean CA, Samson AL, Tyebji S, Tonkin CJ, Bye CR, Turner BJ, Pepin G, Gantier MP, Rogers KL, McArthur K, Crouch PJ, Masters SL. Yu CH, et al. Cell. 2020 Oct 29;183(3):636-649.e18. doi: 10.1016/j.cell.2020.09.020. Epub 2020 Oct 7. Cell. 2020. PMID: 33031745 Free PMC article.

References

    1. Ling JP, et al. Science. 2015;349:650–655. doi: 10.1126/science.aab0983. - DOI - PMC - PubMed
    1. Liu EY, et al. Cell Rep. 2019;27:1409–1421. doi: 10.1016/j.celrep.2019.04.003. - DOI - PMC - PubMed
    1. Barmada SJ, et al. J. Neurosci. 2010;30:639–649. doi: 10.1523/JNEUROSCI.4988-09.2010. - DOI - PMC - PubMed
    1. Chou CC, et al. Nat. Neurosci. 2018;21:228–239. doi: 10.1038/s41593-017-0047-3. - DOI - PMC - PubMed
    1. Swarup V, et al. J. Exp. Med. 2011;208:2429–2447. doi: 10.1084/jem.20111313. - DOI - PMC - PubMed

LinkOut - more resources