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. 2020 Dec;37(6):932-937.
doi: 10.5114/ada.2019.87707. Epub 2019 Sep 4.

Uremic pruritus and serum brain-derived neurotrophic factor in diabetic and non-diabetic haemodialysis patients

Mirosław Śnit  1 , Katarzyna Nabrdalik  1 , Radosław Gawlik  2 , Grzegorz Wystrychowski  1 , Beata Łącka-Gaździk  1 , Roman Kuźniewicz  1 , Janusz Gumprecht  1 , Tomasz Wielkoszyński  3 , Beata Łabuz-Roszak  4 , Władysław Grzeszczak  1
Affiliations

Uremic pruritus and serum brain-derived neurotrophic factor in diabetic and non-diabetic haemodialysis patients

Mirosław Śnit et al. Postepy Dermatol Alergol. 2020 Dec.

Abstract

Introduction: Even though uremic pruritus (UP) is very troublesome for haemodialysis (HD) patients, its underlying mechanism is not fully understood.

Aim: Due to the possible role of brain-derived neurotrophic factor (BDNF) and its higher serum concentration in haemodialysis diabetic patients compared to non-diabetic ones, this study is aimed to evaluate its association with UP among diabetic and non-diabetic patients on maintenance HD.

Material and methods: A total of 94 patients were enrolled into the study. A visual analogue scale (VAS) was used to assess pruritus.

Results: No differences were found between the observed study groups in terms of BDNF serum concentration, other biochemical markers, sleep disturbances, or pruritus presentation.

Conclusions: BDNF serum concentration was not found to be associated with UP among HD patients, however further studies are worth performing on a larger group of individuals.

Keywords: brain-derived neurotrophic factor; diabetes mellitus; haemodialysis; pruritus.

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Conflict of interest statement

The authors declare no conflict of interest.

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