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. 2019 Jun;11(1):376-400.
doi: 10.32614/rj-2019-038. Epub 2019 Aug 20.

SemiCompRisks: An R Package for the Analysis of Independent and Cluster-correlated Semi-competing Risks Data

Danilo Alvares  1 , Sebastien Haneuse  2 , Catherine Lee  3 , Kyu Ha Lee  4
Affiliations

SemiCompRisks: An R Package for the Analysis of Independent and Cluster-correlated Semi-competing Risks Data

Danilo Alvares et al. R J. 2019 Jun.

Abstract

Semi-competing risks refer to the setting where primary scientific interest lies in estimation and inference with respect to a non-terminal event, the occurrence of which is subject to a terminal event. In this paper, we present the R package SemiCompRisks that provides functions to perform the analysis of independent/clustered semi-competing risks data under the illness-death multi-state model. The package allows the user to choose the specification for model components from a range of options giving users substantial flexibility, including: accelerated failure time or proportional hazards regression models; parametric or non-parametric specifications for baseline survival functions; parametric or non-parametric specifications for random effects distributions when the data are cluster-correlated; and, a Markov or semi-Markov specification for terminal event following non-terminal event. While estimation is mainly performed within the Bayesian paradigm, the package also provides the maximum likelihood estimation for select parametric models. The package also includes functions for univariate survival analysis as complementary analysis tools.

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Figures

Figure 1:
Figure 1:
Graphical representation of (a) semi-competing risks and (b) competing risks.
Figure 2:
Figure 2:
Estimated baseline survival (top) and hazard (bottom) functions from the above analysis.
Figure 3:
Figure 3:
Convergence diagnostic via trace plot of multiple chains.
See this image and copyright information in PMC

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