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Case Reports
. 2021 Jan 26;11(1):e7.
doi: 10.5415/apallergy.2021.11.e7. eCollection 2021 Jan.

Primary immunodeficiency from B-cell defect: a case series of 6 patients seen in a national tertiary hospital in the Philippines

Carol Stephanie C Tan-Lim  1 , Mary Anne R Castor  1
Affiliations
Case Reports

Primary immunodeficiency from B-cell defect: a case series of 6 patients seen in a national tertiary hospital in the Philippines

Carol Stephanie C Tan-Lim et al. Asia Pac Allergy. .

Abstract

Primary immunodeficiency disorders, although rare, pose a significant burden in the quality of life of afflicted patients and their families. The most common of these disorders are caused by B-cell defects. A total of 6 patients were seen and diagnosed in a national tertiary hospital in the Philippines from 1996 to 2018. These patients were admitted due to various infections, and were subsequently diagnosed to have B-cell defects. Four out of the 6 patients have genetic studies confirming the diagnosis of X-linked agammaglobulinemia. One patient succumbed to sepsis at 10 years of age, while the rest are on follow-up at the Philippine General Hospital for intravenous immunoglobulin infusion.

Keywords: Agammaglobulinemia; B-lymphocytes; Immune deficiency syndromes.

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Conflict of interest statement

Conflict of Interest: The authors have no financial conflicts of interest.

References

    1. Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP, Jr, Orange JS, Routes JM, Shearer WT, Sorensen RU American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 2005;94(5 Suppl 1):S1–S63. - PubMed
    1. Zelazko M, Carneiro-Sampaio M, Cornejo de Luigi M, Garcia de Olarte D, Porras Madrigal O, Berrón Perez R, Cabello A, Rostan MV, Sorensen RU. Primary immunodeficiency diseases in Latin America: first report from eight countries participating in the LAGID, Latin American Group for Primary Immunodeficiency Diseases. J Clin Immunol. 1998;18:161–166. - PubMed
    1. Stray-Pedersen A, Abrahamsen TG, Frøland SS. Primary immunodeficiency diseases in Norway. J Clin Immunol. 2000;20:477–485. - PubMed
    1. ICD 10 Registry [Internet] Manila (the Philippine): Philippine Pediatric Society, Inc; [cited 2019 Mar 26]. Available from: https://pps.org.ph/icd-10-registry/
    1. Niewiesk S. Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies. Front Immunol. 2014;5:446. - PMC - PubMed

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