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Review
. 2021 Jun;36(5):737-749.
doi: 10.1007/s11011-021-00697-5. Epub 2021 Feb 19.

Emerging role of microRNAs in the pathogenesis of amyotrophic lateral sclerosis

Nader Akbari Dilmaghani  1 , Bashdar Mahmud Hussen  2 , Saeedeh Nateghinia  1 , Mohammad Taheri  3 , Soudeh Ghafouri-Fard  4
Affiliations
Review

Emerging role of microRNAs in the pathogenesis of amyotrophic lateral sclerosis

Nader Akbari Dilmaghani et al. Metab Brain Dis. 2021 Jun.

Abstract

Amyotrophic lateral sclerosis (ALS) is a deadly motor neuron disease (MND) and the most frequent MND in adults. ALS is recognized by degenerative alterations in both upper and lower motor neurons. This disorder is classified to familial and sporadic classes. Disease-causing mutations in SOD1, C9ORF72, FUS, and TARDBP have been recognized in familial ALS cases. However, in spite of conduction of several genetic association studies, heritable genetic risk elements in sporadic have not been identified completely. Several miRNAs have been dysregulated in the serum samples or brain tissues of ALS patients. Moreover, a number of miRNAs have been suggested as putative biomarkers for sporadic ALS. In the current manuscript, we review of miRNAs in the development of ALS.

Keywords: Amyotrophic lateral sclerosis; Biomarker; SOD1; miRNA; microRNA.

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