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Review
. 2021 Jun;11(2):169-177.
doi: 10.2991/jegh.k.201217.001. Epub 2021 Jan 7.

Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review

U Ralapanawa  1 , R Sivakanesan  2
Affiliations
Review

Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review

U Ralapanawa et al. J Epidemiol Glob Health. 2021 Jun.

Abstract

Background: Coronary Artery Disease (CAD) is the foremost single cause of mortality and loss of Disability Adjusted Life Years (DALYs) globally. A large percentage of this burden is found in low and middle income countries. This accounts for nearly 7 million deaths and 129 million DALYs annually and is a huge global economic burden.

Objective: To review epidemiological data of coronary artery disease and acute coronary syndrome in low, middle and high income countries.

Methods: Keyword searches of Medline, ISI, IBSS and Google Scholar databases. Manual search of other relevant journals and reference lists of primary articles.

Results: Review of the results of studies reveals the absolute global and regional trends of the CAD and the importance and contribution of CAD for global health. Data demonstrates which region or countries have the highest and lowest age-standardized DALY rates and what factors might explain these patterns. Results also show differences among the determinants of CAD, government policies, clinical practice and public health measures across the various regions of world.

Conclusion: CAD mortality and prevalence vary among countries. Estimation of the true prevalence of CAD in the population is complex. A significant number of countries have not provided data, the estimation of the exact figures for epidemiological data is a barrier. The incidence of CAD continues to fall in developed countries over the last few decades and this may be due to both effective treatment of the acute phase and improved primary and secondary preventive measures. Developing countries show considerable variability in the incidence of CAD. The globalization of the Western diet and increased sedentary lifestyle will have a dramatic influence on the progressive increase in the incidence of CAD in these countries.

Keywords: Coronary artery disease; acute coronary syndrome; coronary heart disease; epidemiology.

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Conflict of interest statement

The authors declare they have no conflicts of interest.

Figures

Figure 1
Figure 1
Gross National Income ($US) per capita 2005 (World Bank Development Indicators 2007).
Figure 2
Figure 2
Percentage of total mortality attributable to CHD in 2001 by developing region as per WHO Global Burden of Disease and Risk Factors 2006.
See this image and copyright information in PMC

References

    1. Vedanthan R, Seligman B, Fuster V. Global perspective on acute coronary syndrome: a burden on the young and poor. Circ Res. 2014;114:1959–75. doi: 10.1161/CIRCRESAHA.114.302782. - DOI - PMC - PubMed
    1. Nowbar AN, Howard JP, Finegold JA, Asaria P, Francis DP. 2014 Global geographic analysis of mortality from ischaemic heart disease by country, age and income: statistics from World Health Organisation and United Nations. Int J Cardiol. 2014;174:293–8. doi: 10.1016/j.ijcard.2014.04.096. - DOI - PMC - PubMed
    1. Moran AE, Oliver JT, Mirzaie M, Forouzanfar MH, Chilov M, Anderson L, et al. Assessing the Global Burden of Ischemic Heart Disease: part 1: methods for a systematic review of the Global Epidemiology of Ischemic Heart Disease in 1990 and 2010. Glob Heart. 2012;7:315–29. doi: 10.1016/j.gheart.2012.10.004. - DOI - PMC - PubMed
    1. Forouzanfar MH, Moran AE, Flaxman AD, Roth G, Mensah GA, Ezzati M, et al. Assessing the Global Burden of Ischemic Heart Disease: part 2: analytic methods and estimates of the Global Epidemiology of Ischemic Heart Disease in 2010. Glob Heart. 2012;7:331–42. doi: 10.1016/j.gheart.2012.10.003. - DOI - PMC - PubMed
    1. Ounpuu S, Yusuf S. Singapore and coronary heart disease: a population laboratory to explore ethnic variations in the epidemiologic transition. Eur Heart J. 2003;24:127–9. doi: 10.1016/s0195-668x(02)00611-5. - DOI - PubMed

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