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. 2021 Apr;43(4):1056-1062.
doi: 10.1002/hed.26563. Epub 2021 Feb 19.

Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy

Kaveh Zakeri  1 , Huili Wang  1 , Jung Julie Kang  1 , Anna Lee  1 , Paul Romesser  1 , Nader Mohamed  1 , Daphna Gelblum  1 , Eric Sherman  2 , Lara Dunn  2 , Jay Boyle  3 , Richard Wong  3 , Linda Chen  1 , Yao Yu  1 , C Jillian Tsai  1 , Sean M McBride  1 , Nadeem Riaz  1 , Nancy Lee  1
Affiliations

Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy

Kaveh Zakeri et al. Head Neck. 2021 Apr.

Abstract

Background: Proton beam radiation therapy (PBRT) has dosimetric advantages compared to photon radiation therapy for the treatment of major salivary gland tumors (MSGTs).

Methods: Patients with non-metastatic MSGTs treated at a single proton therapy center from October 2013 to October 2018 were retrospectively reviewed.

Results: Sixty-eight patients with MSGTs were included and the most common site and histology were the parotid gland (75.0%) and adenoid cystic carcinoma (22.1%), respectively. The 3-year rates of locoregional control, progression-free survival, and overall survival were 95.1% (95% CI: 89.9%-100.0%), 80.7% (70.2%-92.7%), and 96.1% (95% CI: 90.9%-100.0%), respectively.

Conclusion: In a large cohort of MSGTs treated with PBRT, the rates of locoregional control were high in short-term follow-up and treatment was well tolerated.

Keywords: cancer; proton therapy; radiation; salivary gland; survival.

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Figures

Figure 1.
Figure 1.
Incidence of locoregional failure.
Figure 2.
Figure 2.
Kaplan-Meier plots of progression-free survival (a) and overall survival (b).
See this image and copyright information in PMC

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