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Clinical Trial
. 2021 Jul 1;42(6):e744-e749.
doi: 10.1097/MAO.0000000000003087.

Study on the Bone Metabolism Indices and Otoconin-90 in Benign Paroxysmal Positional Vertigo

Jingtao Bi  1   2 , Bo Liu  1   2 , Yi Zhang  1   2 , Qian Zhou  1   2
Affiliations
Clinical Trial

Study on the Bone Metabolism Indices and Otoconin-90 in Benign Paroxysmal Positional Vertigo

Jingtao Bi et al. Otol Neurotol. .

Abstract

Objective: To investigate the correlation between benign paroxysmal positional vertigo (BPPV) and abnormal bone metabolism and to evaluate the value of otoconial protein otoconin-90 in the pathogenesis research and clinical treatment of BPPV.

Study design: Prospective pilot clinical trial (Level of Evidence: 2b).

Setting: Outpatient otolaryngologic department.

Patients: Twenty seven patients with a diagnosis of BPPV referred to the otolaryngologic department and 25 controls with no history of dizziness from 2018.4 to 2018.9 were reviewed.

Interventions: No.

Main outcome measures: Dual-energy x-ray absorptiometry scanning (DEXA), bone mineral density (BMD) measurement, and assessment of serum levels of otoconin-90 and bone metabolism indices (osteocalcin, OC; 25-OH Vitamin D; total procollagen type 1 N-peptide, TP1NP; β-C-terminal telopeptide of type 1 collagen, β-CTX).

Results: 1) The average serum level of otoconin-90 in the BPPV group was significantly higher than that in the control group (p < 0.05), whereas both the BMD T scores and serum 25-OH Vitamin D levels of the BPPV group were significantly lower than those of the control group (p < 0.05). 2) There was a strong positive correlation between serum otoconin-90 and age (r = 0.44, p < 0.05) and a moderate negative correlation between otoconin-90 and the bone metabolism indices OC (r = -0.33, p > 0.05), 25-OH Vitamin D (r = -0.35, p > 0.05), and TP1NP (r = -0.30, p > 0.05). 3) Logistic regression analysis showed that serum otoconin-90 level was an independent risk factor for BPPV (odd ratio = 0.998, 95% confidence interval 0.997-0.999, p < 0.01).

Conclusion: A correlation between BPPV and abnormal bone metabolism was found. Moreover, otoconin-90 could serve as a research tool for BPPV.

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Conflict of interest statement

Financial disclosure: There are no financial conflicts of interest to disclose. Conflict of interest: The authors declared that they have no conflicts of interest to this work.

References

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    1. Soto-Varela A, Santos-Perez S, Rossi-Izquierdo M, et al. Are the three canals equally susceptible to benign paroxysmal positional vertigo? Audiolo Neurootol 2013; 18:327–334.
    1. Lee SB, Lee CH, Kim YJ, et al. Biochemical markers of bone turnover in benign paroxysmal positional vertigo. PLoS One 2017; 12:e0176011.
    1. Jeong SH, Kim JS, Shin JW, et al. Decreased serum Vitamin D in idiopathic benign paroxysmal positional vertigo. J Neurol 2013; 260:832–838.
    1. Parham K, Kuchel GA, McElhaney JE, et al. A Relationship between blood levels of Otolin-1 and Vitamin D. Otol Neurotol 2018; 39:e269–e273.

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