R.V. is a senior clinical research fellow of the Fund for Scientific Research Flanders (FWO). L.J.C. is supported by a named chair at the KU Leuven funded by Medtronic and a postdoc research fellowship sponsored by the University Hospitals Leuven (KOOR). None of the authors of this manuscript have any conflicts of interest to disclose in relation with this manuscript. The authors confirm that that the work described has not been published previously, that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form in English or in any other language, without the written consent of the copyright holder.