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Review
. 2021 Feb 19;104(4):1188-1201.
doi: 10.4269/ajtmh.20-1536.

Hematological Abnormalities in COVID-19: A Narrative Review

Asma Rahman  1 , Roshan Niloofa  2 , Umesh Jayarajah  3 , Sanjay De Mel  4   5 , Visula Abeysuriya  5 , Suranjith L Seneviratne  5
Affiliations
Review

Hematological Abnormalities in COVID-19: A Narrative Review

Asma Rahman et al. Am J Trop Med Hyg. .

Abstract

COVID-19 is caused by SARS-CoV-2. Although pulmonary manifestations have been identified as the major symptoms, several hematological abnormalities have also been identified. This review summarizes the reported hematological abnormalities (changes in platelet, white blood cell, and hemoglobin, and coagulation/fibrinolytic alterations), explores their patho-mechanisms, and discusses its management. Common hematological abnormalities in COVID-19 are lymphopenia, thrombocytopenia, and elevated D-dimer levels. These alterations are significantly more common/prominent in patients with severe COVID-19 disease, and thus may serve as a possible biomarker for those needing hospitalization and intensive care unit care. Close attention needs to be paid to coagulation abnormalities, and steps should be taken to prevent these occurring or to mitigate their harmful effects. The effect of COVID-19 in patients with hematological abnormalities and recognized hematological drug toxicities of therapies for COVID-19 are also outlined.

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Figures

Figure 1.
Figure 1.
Mechanisms of hematological abnormalities in COVID-19.
See this image and copyright information in PMC

References

    1. WHO , 2020. Coronavirus Disease (COVID-19) Situation Reports. Geneva, Switzerland: World Health Organization. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situatio.... Accessed November 26, 2020.
    1. Jayasinghe R, Ranasinghe S, Jayarajah U, Seneviratne S, 2020. Quality of online information for the general public on COVID-19. Patient Educ Couns 103: 2594–2597. - PMC - PubMed
    1. De Zoysa IM, Seneviratne SL, Abeysuriya V, 2020. Surgical implications of COVID-19. Int J Prog Sci Technol 21: 130–133.
    1. Zhou P, et al. 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579: 270–273. - PMC - PubMed
    1. Jayasekara D, Seneviratne SL, Jayasekara A, De Zoysa I, 2020. Atypical presentations of COVID-19. Adv Infect Dis 10: 136–142.