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. 2021 Sep;18(9):1580-1584.
doi: 10.1513/AnnalsATS.202010-1349RL.

Rates of Major Cardiovascular Events in Severe Asthma: U.S. Real-World and Clinical Trial-Eligible Populations

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Rates of Major Cardiovascular Events in Severe Asthma: U.S. Real-World and Clinical Trial-Eligible Populations

Parul Dayal et al. Ann Am Thorac Soc. 2021 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Age- and sex-standardized rates of cardiovascular events in cohorts of severe asthma patients. ACO = asthma–COPD overlap; CHF = congestive heart failure; COPD = chronic obstructive pulmonary disease; GSA = general severe asthma; HF = heart failure; MI = myocardial infarction; PY = patient-years; TE = trial-eligible; TIA = transient ischemic attack; U. angina = unstable angina.

References

    1. Kennedy-Martin T, Curtis S, Faries D, Robinson S, Johnston J. A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results. Trials. 2015;16:495. - PMC - PubMed
    1. Van Spall HG, Toren A, Kiss A, Fowler RA. Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA. 2007;297:1233–1240. - PubMed
    1. Boyd CM, Vollenweider D, Puhan MA. Informing evidence-based decision-making for patients with comorbidity: availability of necessary information in clinical trials for chronic diseases. PLoS One. 2012;7:e41601. - PMC - PubMed
    1. Herland K, Akselsen JP, Skjønsberg OH, Bjermer L. How representative are clinical study patients with asthma or COPD for a larger “real life” population of patients with obstructive lung disease? Respir Med. 2005;99:11–19. - PubMed
    1. Travers J, Marsh S, Williams M, Weatherall M, Caldwell B, Shirtcliffe P, et al. External validity of randomised controlled trials in asthma: to whom do the results of the trials apply? Thorax. 2007;62:219–223. - PMC - PubMed

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