Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Feb 18;81(4):642-644.
doi: 10.1016/j.molcel.2021.02.003.

A time to build and a time to burn: glucose metabolism for every season

William B McKean  1 , Ashish G Toshniwal  2 , Jared Rutter  3
Affiliations
Free article
Comment

A time to build and a time to burn: glucose metabolism for every season

William B McKean et al. Mol Cell. .
Free article

Abstract

Luengo et al. (2020) demonstrate that pyruvate dehydrogenase (PDH) overactivation blunts NAD+ regeneration by overcharging the mitochondrial membrane potential and driving ATP synthesis beyond demand. Under these conditions, some cells prioritize aerobic glycolysis to meet the need for oxidized cofactors in biosynthetic metabolism.

PubMed Disclaimer

Comment on

  • Increased demand for NAD+ relative to ATP drives aerobic glycolysis.
    Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Luengo A, et al. Mol Cell. 2021 Feb 18;81(4):691-707.e6. doi: 10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30. Mol Cell. 2021. PMID: 33382985 Free PMC article.

Publication types

LinkOut - more resources