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. 2021 Feb 18;184(4):858-860.
doi: 10.1016/j.cell.2021.01.040.

The dural sinus hub: more than just a brain drain

Sarah Mundt  1 , Annika Keller  2 , Melanie Greter  3
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The dural sinus hub: more than just a brain drain

Sarah Mundt et al. Cell. .
Free article

Abstract

Recent findings of an active neuroimmune exchange at brain border regions have challenged the concept of the immune-privileged central nervous system. The study by Rustenhoven et al. in this issue of Cell shows that dural sinuses serve as a conduit for brain-derived antigens to interact with the immune system, allowing in situ immune surveillance.

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  • Functional characterization of the dural sinuses as a neuroimmune interface.
    Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J. Rustenhoven J, et al. Cell. 2021 Feb 18;184(4):1000-1016.e27. doi: 10.1016/j.cell.2020.12.040. Epub 2021 Jan 27. Cell. 2021. PMID: 33508229 Free PMC article.

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