Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb 19;7(1):3.
doi: 10.1186/s40733-021-00069-x.

Asthma and stroke: a narrative review

A Corlateanu  1 , Iu Stratan  2 , S Covantev  2 , V Botnaru  2 , O Corlateanu  3 , N Siafakas  4
Affiliations
Review

Asthma and stroke: a narrative review

A Corlateanu et al. Asthma Res Pract. .

Abstract

Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation, bronchial reversible obstruction and hyperresponsiveness to direct or indirect stimuli. It is a severe disease causing approximately half a million deaths every year and thus possessing a significant public health burden. Stroke is the second leading cause of death and a major cause of disability worldwide. Asthma and asthma medications may be a risk factors for developing stroke. Nevertheless, since asthma is associated with a variety of comorbidities, such as cardiovascular, metabolic and respiratory, the increased incidence of stroke in asthma patients may be due to a confounding effect. The purpose of this review is to analyze the complex relationship between asthma and stroke.

Keywords: ACO; Asthma; Hemorrhagic stroke; ICS; Ischemic stroke; LABA; SABA; SAH.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Overlapping risk factors for asthma and stroke
Fig. 2
Fig. 2
Atherosclerosis as a major pathophysiological mechanism in development of stroke in asthma patients
Fig. 3
Fig. 3
The complex interaction between lungs and the brain
See this image and copyright information in PMC

References

    1. (GINA) Global Strategy for Asthma Management and Prevention. 2020. Available from: https://www.ginasthma.org. Accessed 20 Dec 2020.
    1. Covantev S, Mazuruc N, Uzdenov R, Corlateanu A. Spontaneous Pneumomediastinum – a Rare Asthma Complication. Folia Med. 2019;61:3. - PubMed
    1. Cepelis A, Brumpton BM, Laugsand LE, Langhammer A, Janszky I, Strand LB. Asthma, asthma control and risk of ischemic stroke: The HUNT study. Respir Med. 2020 2020/11/01/;2:100013.
    1. Raita Y, Camargo CA, Faridi MK, Brown DFM, Shimada YJ, Hasegawa K. Risk of Acute Myocardial Infarction and Ischemic Stroke in Patients with Asthma Exacerbation: A Population-Based, Self-Controlled Case Series Study. J Allerg Clin Immunol. 2020 2020/01/01/;8(1):188–194. e8. - PubMed
    1. Zeiger R, Sullivan P, Chung Y, Kreindler JL, Zimmerman NM, Tkacz J. Systemic Corticosteroid-Related Complications and Costs in Adults with Persistent Asthma. J Allerg Clin Immunol. 2020 2020/11/01/; 8(10):3455–3465.e13. - PubMed

LinkOut - more resources