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Case Reports
. 2021 Mar;35(3):920-923.
doi: 10.1038/s41375-021-01175-8. Epub 2021 Feb 19.

Severe clinical relapse in an immunocompromised host with persistent SARS-CoV-2 infection

Philipp A Reuken  1 , Andreas Stallmach  2 , Mathias W Pletz  3 , Christian Brandt  3 , Nico Andreas  4 , Sabine Hahnfeld  5 , Bettina Löffler  6 , Sabine Baumgart  4   7 , Thomas Kamradt  4   7 , Michael Bauer  8
Affiliations
Case Reports

Severe clinical relapse in an immunocompromised host with persistent SARS-CoV-2 infection

Philipp A Reuken et al. Leukemia. 2021 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1
Fig. 1. t-SNE map of blood leukocytes after exclusion of granulocytes.
Cells were stained with 30 antibodies for cell surface molecules and analyzed by mass cytometry. Main leukocyte populations were assigned according to their marker expression (Supplementary Table 2) pDC: plasmacytoid dendritic cells, mDC: myeloid dendritic cells. The t-SNE maps A (controls) and B (patients) are colored according to their cell densities (red indicates the highest cell density). A complete absence of B cells in the patient is shown.
Fig. 2
Fig. 2. Analysis of leukocyte subpopulations of the patient.
A–D Absolute numbers of CD3 + T cells and percentages of CD3 + CD8 + cytotoxic T cells and CD3 + CD4 + T helper (Th) cells in the blood of the patient (black bars) and six controls (gray bars). E–H Frequencies of Th1 (CXCR3+CCR6−CCR4−CXCR5−), Th2 (CXCR3−CCR6−CCR4+ CXCR5−), Th17 (CXCR3−CCR6+CCR4+CXCR5−), and Treg (CD25+CD127−CCR4+HLA-DR−) cells among CD3+CD4+ T cells in the patient (black bars) and controls (gray bars).
See this image and copyright information in PMC

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