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Case Reports
. 2021 Jun;14(3):810-814.
doi: 10.1007/s12328-021-01362-1. Epub 2021 Feb 19.

HPV-16-associated lymphoepithelial-like carcinoma mimicking rectal tonsil

Pallavi Kopparthy  1 , Joanna Chaffin  2 , Michael M Feely  2 , Hiral D Parekh  3
Affiliations
Case Reports

HPV-16-associated lymphoepithelial-like carcinoma mimicking rectal tonsil

Pallavi Kopparthy et al. Clin J Gastroenterol. 2021 Jun.

Abstract

Lymphoepithelial-like carcinoma is a rare malignancy characterized by lack of cellular differentiation and associated nonneoplastic lymphoplasmacytic cell infiltrate that is rarely seen in the colon. Although many cases are associated with EBV infection, HPV may be present in LELC arising in sites known for HPV-driven malignancies, like the anogenital region. We report a case of lymphoepithelial-like carcinoma mimicking a rectal tonsil in a 51-year-old female. Attentive evaluation must be taken to identify this tumor in locations where prominent lymphoid stroma is an expected finding.

Keywords: Lymphoepithelial-like carcinoma (LELC); Lymphoid tumor; Rectal tonsil.

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References

    1. Wenig MB. Lymphoepithelial-like carcinomas of the head and neck. Semin Diagn Pathol. 2015;32(74–8):6.
    1. Xue J, Yu H, Yan J, et al. Non-Epstein-Barr virus-associated double primary lymphoepithelioma-likecarcinoma of the esophagus and stomach: a case report andliterature review. Int J Clin Exp Med. 2015;8:10051–7. - PubMed - PMC
    1. Vilor M, Tsutsumi Y. Localization of Epstein-Barr virus genomein lymphoid cells in poorly differentiated adenocarcinoma with lymphoid stroma of the colon. Pathol Int. 1995;45:695–7. - DOI
    1. Palazzo J, Mittal RK. Lymphoepithelioma-like carcinoma of the rectum in a patient with ulcerative colitis. Am J Gastroenterol. 1996;91(2):398–9. - PubMed
    1. Samaha S, Tawfik O, Horvat R, et al. Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. Dis Colon Rectum. 1998;41:925–8. - DOI

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