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. 2021 May;38(5):1177-1186.
doi: 10.1007/s10815-021-02072-w. Epub 2021 Feb 19.

Elective oocyte cryopreservation for age-related fertility decline

E Chronopoulou  1 , C Raperport  2   3 , A Sfakianakis  2 , G Srivastava  2 , R Homburg  2
Affiliations

Elective oocyte cryopreservation for age-related fertility decline

E Chronopoulou et al. J Assist Reprod Genet. 2021 May.

Abstract

Purpose: Women who pursue fertility at an advanced age are increasingly common. Family planning and sexual education have traditionally focused on contraception and prevention of sexually transmitted diseases. A focus should now also be placed on fertility awareness and fertility preservation. This manuscript aims to give an update on the existing evidence around elective oocyte cryopreservation, also highlighting the need for fertility education and evidence-based, individualized counselling.

Methods: A thorough electronic search was performed from the start of databases to March 2020 aiming to summarize the existing evidence around elective egg freezing, the logic behind its use, patient counselling and education, success rates and risks involved, regulation, cost-effectiveness, current status and future perspectives.

Results: Clinician-led counselling regarding reproductive aging and fertility preservation is often overlooked. Elective oocyte cryopreservation is not a guarantee of live birth, and the answer regarding cost-effectiveness needs to be individualized. The existing studies on obstetric and perinatal outcomes following the use of egg freezing are, until now, reassuring. Constant monitoring of short-term and long-term outcomes, uniform regulation and evidence-based, individualized counselling is of paramount importance.

Conclusions: Elective oocyte cryopreservation is one of the most controversial aspects of the world of assisted reproduction, and a lot of questions remain unanswered. However, women today do have this option which was not available in the past. Elective oocyte cryopreservation for age-related fertility decline should be incorporated in women's reproductive options to ensure informed decisions and reproductive autonomy.

Keywords: ART; Cryopreservation; Egg freezing; Fertility preservation; Slow freezing; Vitrification.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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