Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Jun;73(3):769-780.
doi: 10.1007/s43440-021-00233-3. Epub 2021 Feb 20.

In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis

Hikmat Permana  1 , Ian Huang  2 , Aga Purwiga  2 , Nuraini Yasmin Kusumawardhani  3 , Teddy Arnold Sihite  3 , Erwan Martanto  3 , Rudi Wisaksana  4 , Nanny Natalia M Soetedjo  5
Affiliations
Meta-Analysis

In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis

Hikmat Permana et al. Pharmacol Rep. 2021 Jun.

Abstract

Background and aims: The idea of treating COVID-19 with statins is biologically plausible, although it is still controversial. The systematic review and meta-analysis aimed to address the association between the use of statins and risk of mortality in patients with COVID-19.

Methods: Several electronic databases, including PubMed, SCOPUS, EuropePMC, and the Cochrane Central Register of Controlled Trials, with relevant keywords up to 11 November 2020, were used to perform a systematic literature search. This study included research papers containing samples of adult COVID-19 patients who had data on statin use and recorded mortality as their outcome of interest. Risk estimates of mortality in statin users versus non-statin users were pooled across studies using inverse-variance weighted DerSimonian-Laird random-effect models.

Results: Thirteen studies with a total of 52,122 patients were included in the final qualitative and quantitative analysis. Eight studies reported in-hospital use of statins; meanwhile, the remaining studies reported pre-admission use of statins. In-hospital use of statin was associated with a reduced risk of mortality (RR 0.54, 95% CI 0.50-0.58, p < 0.00001; I2: 0%, p = 0.87), while pre-admission use of statin was not associated with mortality (RR 1.18, 95% CI 0.79-1.77, p = 0.415; I2: 68.6%, p = 0.013). The funnel plot for the association between the use of statins and mortality were asymmetrical.

Conclusion: This meta-analysis showed that in-hospital use of statins was associated with a reduced risk of mortality in patients with COVID-19.

Keywords: COVID-19; In-hospital; Mortality; Pre-admission; SARS-CoV-2; Statins.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Study flow diagram
Fig. 2
Fig. 2
Forest plot showing overall effect estimates of in-hospital use of statins and mortality in patients with COVID-19. RR Relative Risk, CI Confidence Interval
Fig. 3
Fig. 3
Forest plot showing overall effect estimates of pre-admission use of statins and mortality in patients with COVID-19. RR Relative Risk, CI Confidence Interval
Fig. 4
Fig. 4
Funnel-plot analysis. a In-hospital and b Pre-admission use of statins and mortality in patients with COVID-19. CI Confidence Interval
See this image and copyright information in PMC

References

    1. Pranata R, Supriyadi R, Huang I, Permana H, Lim MA, Yonas E, et al. The association between chronic kidney disease and new onset renal replacement therapy on the outcome of COVID-19 patients: a meta-analysis. Clin Med Insights Circ Respir Pulm Med. 2020;14:1179548420959165. doi: 10.1177/1179548420959165. - DOI - PMC - PubMed
    1. Andhika R, Huang I, Wijaya I. The severity of COVID-19 in end-stage kidney disease patients on chronic dialysis. Ther Apher Dial. 2020;50(1744–9987):13597. doi: 10.1111/1744-9987.13597. - DOI - PMC - PubMed
    1. Wijaya I, Andhika R, Huang I. Hypercoagulable state in COVID-19 with diabetes mellitus and obesity: is therapeutic-dose or higher-dose anticoagulant thromboprophylaxis necessary? Diabetes Metab Syndr Clin Res Rev. 2020;14:1241–1242. doi: 10.1016/j.dsx.2020.07.015. - DOI - PMC - PubMed
    1. Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Gutierrez EJ, et al. Effect of heart failure on the outcome of COVID-19—a meta analysis and systematic review. Am J Emerg Med. 2020;155:104743. doi: 10.1016/j.ajem.2020.07.009. - DOI - PMC - PubMed
    1. Wijaya I, Andhika R, Huang I. The use of therapeutic-dose anticoagulation and its effect on mortality in patients with COVID-19: a systematic review. Clin Appl Thromb. 2020 doi: 10.1177/1076029620960797. - DOI - PMC - PubMed

Substances

LinkOut - more resources