Time trends in incidence and survival of small intestinal cancer in Sweden

Abstract

Background: Small intestinal cancer is less common than some other gastrointestinal malignancies. Tumours of different histological types and anatomical sites of origin have therefore often been described together. The aim of this study was to investigate the epidemiology for each of the four main subtypes: duodenal adenocarcinoma (D-AC), duodenal neuroendocrine tumour (D-NET), jejunoileal adenocarcinoma (J/I-AC), and jejunoileal neuroendocrine tumour (J/I-NET).

Methods: All patients with small intestinal cancer diagnosed between 1960 and 2015 were identified from the Swedish Cancer Register. The age-adjusted incidence rate with incidence rate ratios, as well as overall (OS) and net (NS) survival, were determined and temporal trends were analysed.

Results: The incidence rate was highest for J/I-NET, with 9.98 clinical diagnoses per million in 2010-2015. Clinical diagnosis of D-AC increased more than 10-fold and surpassed J/I-AC as the second most common subtype. D-NET was by far the least common subtype. Diagnosis at autopsy became less common over time, whereas clinical diagnoses increased significantly for all four subtypes. All subtypes except J/I-AC affected men more often than women. The age distribution was similar between subtypes, although patients with adenocarcinomas were slightly older. Survival was generally much better for patients with NET than for those with adenocarcinoma. Both OS and NS showed a negative association with advancing age. Survival improved only for J/I-NET from a 5-year NS of 0.69 in the 1960s to 0.81 in 2010-2015.

Conclusion: The incidence of small intestinal cancer is increasing, particularly for D-AC and in the elderly. Survival of patients with small intestinal cancer has improved only for J/I-NET over the last decades.

Fig. 1

Temporal trends of age-adjusted clinical and overall (including autopsy) incidence of small intestinal cancer subtypes, 1960–2015 J/I-NET, jejunoileal neuroendocrine tumour; D-AC, duodenal adenocarcinoma; J/I-AC, jejunoileal adenocarcinoma; D-NET, duodenal neuroendocrine tumour.

Fig. 2

Incidence of small intestinal cancer subtypes at different ages J/I-NET, jejunoileal neuroendocrine tumour; D-AC, duodenal adenocarcinoma; J/I-AC, jejunoileal adenocarcinoma; D-NET, duodenal neuroendocrine tumour.

Fig. 3

Kaplan–Meier curves for overall survival in small intestinal cancer subtypes of patients diagnosed from 2000 onwards later J/I-NET, jejunoileal neuroendocrine tumour; D-AC, duodenal adenocarcinoma; J/I-AC, jejunoileal adenocarcinoma; D-NET, duodenal neuroendocrine tumour.

Fig. 4

Net survival in small intestinal cancer subtypes J/I-NET, jejunoileal neuroendocrine tumour; D-AC, duodenal adenocarcinoma; J/I-AC, jejunoileal adenocarcinoma; D-NET, duodenal neuroendocrine tumour.