doi: 10.1111/j.1476-5381.1977.tb08400.x.
Effect of intrahypothalamic phentolamine on hypothermia produced by peripheral noradrenaline in the pigeon
- PMID: 336125
- PMCID: PMC1667512
- DOI: 10.1111/j.1476-5381.1977.tb08400.x
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Effect of intrahypothalamic phentolamine on hypothermia produced by peripheral noradrenaline in the pigeon
Br J Pharmacol.
1977 Oct.
Abstract
1 The effect of intrahypothalamic phentolamine (1 and 1 microliter of a 10 microgram/microliter solution) on hypothermia induced by intramuscular injection of noradrenaline (NA, 2 mg/kg) at different times (2, 10, 20 min) after phentolamine was investigated in pigeons. 2 Administration of phentolamine shortly before NA was shown to attenuate hypothermic responses to NA. 3 It is suggested that the attenuation is due to blockade of central hypothermic effects of intramuscular NA. 4 The mapping of injection sites in the brains was carried out.
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