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Review
. 2021;27(1):46-48.
doi: 10.1007/s12268-021-1512-x. Epub 2021 Feb 12.

COR-101, ein menschlicher Antikörper gegen COVID-19

[Article in German]
Stefan Dübel  1 , Andreas Herrmann  2 , Thomas Schirrmann  2   3 , André Frenzel  2   3 , Michael Hust  1
Affiliations
Review

COR-101, ein menschlicher Antikörper gegen COVID-19

[Article in German]
Stefan Dübel et al. Biospektrum (Heidelb). 2021.

Abstract

COR-101 is a fully human, Fc silenced IgG that was discovered by antibody phage display. It reduced the SARS-CoV-2 virus load in the lung by more than 99 percent in Hamster models and led to much faster recovery. Its mode of action has been elucidated by solving the atomic structure of its interaction with SARS-CoV-2. The antibody competes with ACE2 binding by blocking a large area of the SARS-CoV-2 spike protein.

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