Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021;27(1):49-53.
doi: 10.1007/s12268-021-1516-6. Epub 2021 Feb 12.

Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir

[Article in German]
Patrick Cramer  1 , Goran Kokic  1 , Christian Dienemann  1 , Claudia Höbartner  2 , Hauke S Hillen  1   3
Affiliations
Review

Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir

[Article in German]
Patrick Cramer et al. Biospektrum (Heidelb). 2021.

Abstract

Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 polymerase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme synthesizes RNA and how it replicates the exceptionally large genome in a processive manner. The most recent structure-function studies further reveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19.

PubMed Disclaimer

References

    1. Hilgenfeld R, Peiris M. From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Res. 2013;100:286–295. doi: 10.1016/j.antiviral.2013.08.015. - DOI - PMC - PubMed
    1. Snijder EJ, Decroly E, Ziebuhr J. The nonstructural proteins directing coronavirus RNA synthesis and processing. Adv Virus Res. 2016;96:59–126. doi: 10.1016/bs.aivir.2016.08.008. - DOI - PMC - PubMed
    1. Osman S, Cramer P. Structural biology of RNA polymerase II transcription: 20 years On. Annu Rev Cell Dev Biol. 2020;36:1–34. doi: 10.1146/annurev-cellbio-042020-021954. - DOI - PubMed
    1. Cramer P. Organization and regulation of gene transcription. Nature. 2019;573:45–54. doi: 10.1038/s41586-019-1517-4. - DOI - PubMed
    1. Cramer P. Eukaryotic transcription turns 50. Cell. 2019;179:808–812. doi: 10.1016/j.cell.2019.09.018. - DOI - PubMed