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. 2021 Feb 3:15:621080.
doi: 10.3389/fnhum.2021.621080. eCollection 2021.

Functional Disconnection of the Angular Gyrus Related to Cognitive Impairment in Patients With Type 2 Diabetes Mellitus

Fei Qi  1 , Dongsheng Zhang  1 , Jie Gao  1 , Min Tang  1 , Man Wang  2 , Yu Su  2 , Yumeng Lei  2 , Zhirong Shao  2 , Xiaoling Zhang  1
Affiliations

Functional Disconnection of the Angular Gyrus Related to Cognitive Impairment in Patients With Type 2 Diabetes Mellitus

Fei Qi et al. Front Hum Neurosci. .

Abstract

Type 2 diabetes mellitus (T2DM) is related to a variety of cognitive impairments that may even progress to dementia. Studies have found the angular gyrus (AG) is a cross-modal integration hub that is involved in a variety of cognitive processes. However, few studies have focused on the patterns of resting-state functional connections (rsFCs) of the AG in patients with T2DM. This study explored the functional connection (FC) between the AG and the whole brain and the relationship between the FC and clinical/cognitive variables in patients with T2DM. 44 patients with T2DM and 43 sex-, age-, and education-matched healthy controls underwent resting-state fMRI and received neuropsychological assessments. Compared with the control group, the T2DM group showed abnormal rsFCs between the AG and multiple brain regions. The FC between the left AG and the left medial temporal lobe in the T2DM group was positively correlated with scores on the Montreal Cognitive Assessment, after a Bonferroni correction (r = 0.40, P = 0.009). Collectively, patients with T2DM have abnormal FCs between the AG and extensive brain regions that may be related to various cognitive processes.

Keywords: angular gyrus; functional connectivity; neuroimaging; resting-state fMRI; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Differences in resting-state functional connectivity between the T2DM group and the HC group (two-sample t-test, P < 0.05, Gaussian random field-corrected). (A) Lower connectivity of the left AG in the T2DM group. (B) Lower connectivity of the right AG in the T2DM group.
FIGURE 2
FIGURE 2
Significant correlation between the FC of the AG and neuropsychological performances in the T2DM group. (A) Significant positive correlation of MoCA scores with the FC between the left AG and the left MTL. (B) Significant negative correlation of diabetes duration with the FC between the left AG and the right MFG. AG: angular gyrus; MTL: medial temporal lobe; MFG: middle frontal gyrus; MoCA: Montreal Cognitive Assessment.
See this image and copyright information in PMC

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