Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan;13(1):26-37.
doi: 10.14740/jocmr4405. Epub 2021 Jan 12.

Outcomes in Patients With COVID-19 Disease and High Oxygen Requirements

Geurys Rojas-Marte  1   2 , Arsalan Talib Hashmi  1 , Mazin Khalid  1 , Nnamdi Chukwuka  3 , Joshua Fogel  4 , Alejandro Munoz-Martinez  3 , Samantha Ehrlich  3 , Maham Akbar Waheed  3 , Dikshya Sharma  3 , Shaurya Sharma  3 , Awais Aslam  3 , Sabah Siddiqui  1 , Chirag Agarwal  1 , Yuri Malyshev  1 , Carlos Henriquez-Felipe  1 , Jacob Shani  1
Affiliations

Outcomes in Patients With COVID-19 Disease and High Oxygen Requirements

Geurys Rojas-Marte et al. J Clin Med Res. 2021 Jan.

Abstract

Background: Approximately 19% of people infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progress to severe or critical stages of the coronavirus disease 2019 (COVID-19) with a mortality rate exceeding 50%. We aimed to examine the characteristics, mortality rates, intubation rate, and length of stay (LOS) of patients hospitalized with COVID-19 disease with high oxygen requirements (critically ill).

Methods: We conducted a retrospective analysis in a single center in Brooklyn, New York. Adult hospitalized patients with confirmed COVID-19 disease and high oxygen requirements were included. We performed multivariate logistic regression analyses for statistically significant variables to reduce any confounding.

Results: A total of 398 patients were identified between March 19th and April 25th, 2020 who met the inclusion criteria, of which 247 (62.1%) required intubation. The overall mortality rate in our study was 57.3% (n = 228). The mean hospital LOS was 19.1 ± 17.4 days. Patients who survived to hospital discharge had a longer mean LOS compared to those who died during hospitalization (25.4 ± 22.03 days versus10.7 ± 1.74 days). In the multivariate analysis, increased age, intubation and increased lactate dehydrogenase (LDH) were each independently associated with increased odds of mortality. Diarrhea was associated with decreased mortality (OR 0.4; CI 0.16, 0.99). Obesity and use of vasopressors were each independently associated with increased intubation.

Conclusions: In patients with COVID-19 disease and high oxygen requirements, advanced age, intubation, and higher LDH levels were associated with increased mortality, while diarrhea was associated with decreased mortality. Gender, diabetes, and hypertension did not have any association with mortality or length of hospital stay.

Keywords: COVID-19 disease; Critically ill; High oxygen requirement; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

None to declare.

Figures

Figure 1
Figure 1
Complications in patients with COVID-19 disease and high oxygen requirements.
See this image and copyright information in PMC

References

    1. Epidemiology Working Group for Ncip Epidemic Response, Chinese Center for Disease Control Prevention. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China] Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145–151. - PubMed
    1. Chan JF, To KK, Tse H, Jin DY, Yuen KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol. 2013;21(10):544–555. doi: 10.1016/j.tim.2013.05.005. - DOI - PMC - PubMed
    1. Center JHCR. Johns Hopkins Coronavirus Resource Center.
    1. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. doi: 10.1001/jama.2020.2648. - DOI - PubMed
    1. Argenziano MG, Bruce SL, Slater CL, Tiao JR, Baldwin MR, Barr RG, Chang BP. et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series. BMJ. 2020;369:m1996. doi: 10.1136/bmj.m1996. - DOI - PMC - PubMed

LinkOut - more resources