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. 2021 Feb 18;14(2):326-329.
doi: 10.18240/ijo.2021.02.23. eCollection 2021.

Accelerated growth of uveal melanoma related to pregnancy: a case report and literature review

Han Yue  1   2 , Jiang Qian  1   2 , Hui Ren  1   2 , Rui Zhang  1   2 , Lu Gan  1   2 , Ying-Wen Bi  3
Affiliations

Accelerated growth of uveal melanoma related to pregnancy: a case report and literature review

Han Yue et al. Int J Ophthalmol. .
No abstract available

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Figures

Figure 1
Figure 1. Clinical features and imaging examinations of the case, a 25-year-old woman with uveal melanoma during pregnancy
A: Photo of the slit-lamp examination shows a black mass under the temporal congestive bulbar conjunctiva; B: Fundus of the right eye showing pigmented spots in the posterior pole and a big bunch with shadow retinal detachment at the temporal site; C: B-scan ultrasound showing multifocal thickening of the choroid at 3.05 mm at the thickest point and a low-echo area of 7.71×10.53 mm2 behind the eyeball; D-F: MRI scan showing thickening of the back wall of the eyeball and a round mass adjoining the outer wall of the temporal eyeball, both with a higher signal in T1 WI (D), lower signal in T2 WI (E), and moderately-enhanced signal when injected with contrast agent (F).
Figure 2
Figure 2. Pathological examinations and follow-up of the case
A and B: Pathological images of the tumor with hematoxylin and eosin (HE) staining show mixed-cell-type melanoma; C and D: Immunohistochemical staining of the estrogen (C) and progesterone (D) receptors shows negative staining with depigmentation of the tumor; the images inserted show a positive control from a case of cervical cancer; E: A T1-enhanced MRI scan shows complete tumor and eyeball removal; F: Doppler ultrasound could not detect any blood supply at the operation site one year later. Asterisk: Tumor cells outside of the sclera; Arrowhead: Tumor cells in the choroid; Pound: Sclera. A: 50×; B-D: 400×.
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