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. 2021 Feb 4:8:2333794X21990338.
doi: 10.1177/2333794X21990338. eCollection 2021.

Growth Trajectories of HIV Exposed and HIV Unexposed Infants. A Prospective Study in Gweru, Zimbabwe

Lucy Mabaya  1   2 , Hilda Tendisa Matarira  2 , Donald Moshen Tanyanyiwa  3 , Cuthbert Musarurwa  2 , Johannes Mukwembi  1
Affiliations

Growth Trajectories of HIV Exposed and HIV Unexposed Infants. A Prospective Study in Gweru, Zimbabwe

Lucy Mabaya et al. Glob Pediatr Health. .

Abstract

Background: With the increasing HIV seroprevalence among women of childbearing age in sub-Saharan Africa, limited data on growth outcomes of HIV exposed infants under current policies of universal maternal antiretroviral therapy exist.

Methods: The longitudinal growth patterns of 114 HIV exposed and unexposed infants were assessed and compared. The prevalence and factors associated with malnutrition were established. Infants under prevention of mother to child transmission care were recruited at 6 weeks post-delivery as were their HIV unexposed counterparts. Weight and length measurements were recorded at birth, 6 and 16 weeks postpartum.

Results: HIV vertical transmission rate was 8.8%. HIV exposed infants had significantly lower mean birth weights compared to HIV unexposed infants (2.9 ± 0.3; 3.2 ± 0.5; P < .001) respectively. Mean weight/length-for-age z-scores for HIV exposed, uninfected (HEU) infants were significantly below those of the HIV unexposed infants during follow up. By 6 weeks of age, 28.5% of HEU infants were malnourished while no malnutrition was evident in HIV unexposed infants. A gestational age <37 weeks (OR: 3.83; 95% CI: 1.03-14.30; P = .045) and HIV exposure (OR: 1.62; 95% CI: 0.17-15.73; P = .017) substantially increased the risk of stunting.

Conclusion: Growth deficits were witnessed in HIV exposed infants compared to HIV unexposed infants. There is need for early nutritional monitoring and support among HIV exposed infants.

Keywords: HIV; antiretroviral therapy; growth; infants.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. AIDS and TB Programme, Primary Health Care, National AIDS Council. Zimbabwe National and Sub-National HIV Estimates Report 2017. Ministry of Health and Child Care, Zimbabwe; 2018.
    1. Jagadish DMH, Gudegowda KS, Sobagaiah RT, Neela VV. Knowledge, attitude and practice among private medical professionals enrolled in public private partnership program for prevention of mother to child transmission of human immunodeficiency virus in three districts of Karnataka. Int J Community Med Public Health. 2019;6:4381-4386.
    1. Slogrove AL, Becquet R, Chadwick EG, et al. Surviving and thriving-shifting the public health response to HIV-exposed uninfected children: report of the 3rd HIV-Exposed Uninfected Child Workshop. Front Pediatr. 2018;6:157. - PMC - PubMed
    1. Ahmed S, Kim MH, Abrams EJ. Risks and benefits of lifelong antiretroviral treatment for pregnant and breastfeeding women: a review of the evidence for the Option B+ approach. Curr Opin HIV AIDS. 2013;8: 474-489. - PubMed
    1. Evans C, Jones CE, Prendergast AJ. HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination. Lancet Infect Dis. 2016;16:e92-e107. - PubMed

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