Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 14;7(1):e12127.
doi: 10.1002/trc2.12127. eCollection 2021.

Lumbar puncture patient video increases knowledge and reduces uncertainty: An RCT

Rosha Babapour Mofrad  1   2 , Agnetha D Fruijtier  2   3 , Leonie N C Visser  2   3 , Nina Hoogland  2 , Maisa van Dijk  4 , Frederique van Rossum  4 , Femke H Bouwman  2 , Ellen M A Smets  3 , Charlotte E Teunissen  1 , Wiesje M van der Flier  2   5
Affiliations

Lumbar puncture patient video increases knowledge and reduces uncertainty: An RCT

Rosha Babapour Mofrad et al. Alzheimers Dement (N Y). .

Abstract

Background: Patients often perceive a lumbar puncture (LP) as an invasive procedure. We aimed to evaluate the impact of a 3-minute educational animation-video explaining the LP procedure, on patients' knowledge, uncertainty, anxiety, and post-LP complications.

Methods: We included 203 newly referred memory clinic patients, who were randomly assigned to one of three conditions: (1) home viewing of the video, (2) clinic viewing of the video, or (3) control condition (care as usual). Participants completed questionnaires measuring knowledge as information recall, uncertainty, anxiety, and post-LP complications, the latter when patients underwent an LP procedure (n = 145).

Results: Viewing the video increased information recall for both home (P < .001), and clinic viewers (P < .001) compared to controls. Levels of uncertainty decreased after viewing (Pfor interaction = .044), particularly for clinic viewers. Viewing the video or not did not affect anxiety and post-LP complications.

Discussion: Preparing individuals for an LP by means of an educational video can help to increase knowledge about the procedure and reduce feelings of uncertainty.

Keywords: Alzheimer's disease; educational animation‐video; information provision; lumbar puncture; memory clinics; patient education; post‐lumbar puncture complications.

PubMed Disclaimer

Conflict of interest statement

The authors have declared no conflicts of interest for this article.

Figures

FIGURE 1
FIGURE 1
Study population flowchart. Abbreviations: Covid‐19, corona virus disease 2019; LP, lumbar puncture
FIGURE 2
FIGURE 2
Schematic overview of the study
FIGURE 3
FIGURE 3
Estimated marginal means for uncertainty (Mishel Uncertainty in Illness Scale; A) and anxiety (State‐Trait Anxiety Inventory; B) at T1 and T2, with 95% confidence intervals. Analysis of variance (ANOVA) for repeated measures showed an effect of the intervention on the decrease in uncertainty (F[2, 183] = 5.02, Pfor interaction = .008). Here, clinic viewing showed the strongest decline in uncertainty over time, compared to both home viewing, and the control condition, though post hoc analyses did not yield significant differences between conditions. ANOVA for repeated measures for anxiety did not show an effect of the intervention on anxiety over time (F[2, 185] = .44, Pfor interaction  = .64). Green dotted line = C1: home viewing, orange line = C2: clinic viewing, and purple dashed line = C3: control condition
FIGURE 4
FIGURE 4
Scatterplots present the association between outcome measures, and outcome measures and patient‐related factors. Of note, a positive Δ uncertainty or Δ anxiety over time (eg, +1) equals a decrease in uncertainty or anxiety over time, and vice versa
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. The Lancet Neurology. 2003;2:605‐613. - PubMed
    1. Hulstaert F, Blennow K, Ivanoiu A, et al. Improved discrimination of AD patients using b‐amyloid(1‐42) and tau levels in CSF. Neurology. 1999;52:1555‐1576. - PubMed
    1. Mulder C, Verwey NA, van der Flier WM, et al. Amyloid‐beta(1‐42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clin Chem. 2010;56:248‐253. - PubMed
    1. Blennow K, Dubois B, Fagan AM, Lewczuk P, de Leon MJ, Hampel H. Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease. Alzheimers Dement. 2015;11:58‐69. - PMC - PubMed
    1. Zetterberg H, Tullhog K, Hansson O, Minthon L, Londos E, Blennow K. Low incidence of post‐lumbar puncture headache in 1,089 consecutive memory clinic patients. Eur Neurol. 2010;63:326‐330. - PubMed

LinkOut - more resources