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Review
. 2021 Apr;21(4):e2100007.
doi: 10.1002/mabi.202100007. Epub 2021 Feb 22.

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Yunqi Guo  1 , Mingwu Shen  1 , Xiangyang Shi  1
Affiliations
Review

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Yunqi Guo et al. Macromol Biosci. 2021 Apr.

Abstract

Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system due to their stable fluorescence property and excellent biocompatibility. The distinctive merits of PAMAM dendrimers and CDs are amenable for them to be constructed as perfect nanohybrids for different biomedical applications, in particular for cancer nanomedicine. Here, the recent advances in the construction of PAMAM dendrimer/CD nanohybrids for diverse biomedical applications, in particular for sensing and cancer theranostics are summarized. Finally, the future perspectives of the PAMAM dendrimer/CD nanohybrids are also briefly discussed.

Keywords: cancer theranostics; carbon dots; poly(amidoamine) dendrimers; sensing.

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