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. 2022 Mar;36(6):1616-1620.
doi: 10.1080/14786419.2021.1887868. Epub 2021 Feb 22.

A new cytotoxic compound from the leaves of Styrax annamensis Guillaumin

Nguyen Thanh Tra  1   2 , Ninh The Son  1 , Nguyen Van Tuyen  1 , Pham Van Cuong  3 , Nguyen Thi Thu Ha  1   2 , Le Thi Tu Anh  1 , Doan Thi Mai Huong  3 , Truong Bich Ngan  3 , Marc Litaudon
Affiliations

A new cytotoxic compound from the leaves of Styrax annamensis Guillaumin

Nguyen Thanh Tra et al. Nat Prod Res. 2022 Mar.

Abstract

New propene derivative 1-(3',4'-methylenedioxyphenyl)-2-(2''-hydroxy-5-(3'''-hydroxypropyl)-3''-methoxyphenyl)prop-2-en-1-one (1), along with three known triterpenoids ursolic acid (2), pomolic acid (3), and maslinic acid (4) were isolated from the leaves of Styrax annamensis species. All structures were assigned by spectroscopic analysis. Compound 1 showed potent cytotoxicity against four cancer cell lines (KB, HepG2, Lu, and MCF7) with the IC50 values of 3.19, 2.87, 2.33, and 2.44 µM, respectively.

Keywords: Styrax annamensis; cytotoxicity; leaves; phytochemistry.

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