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Review
. 2021 Apr 3;32(3):325-330.
doi: 10.1080/09537104.2021.1887842. Epub 2021 Feb 22.

Platelets and viruses

Silvio Antoniak  1   2 , Nigel Mackman  1   3
Affiliations
Review

Platelets and viruses

Silvio Antoniak et al. Platelets. .

Abstract

Platelets play an essential role in maintaining vascular integrity after injury. In addition, platelets contribute to the immune response to pathogens. For instance, they express receptors that mediate binding of viruses, and toll-like receptors that activate the cell in response to pathogen-associated molecular patterns. Platelets can be beneficial and/or detrimental during viral infections. They reduce blood-borne viruses by engulfing the free virus and presenting the virus to neutrophils. However, platelets can also enhance inflammation and tissue injury during viral infections. Here, we discuss the roles of platelets in viral infection.

Keywords: Platelets; coronavirus; influenza A virus; myocarditis.

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Conflict of interest statement

Declaration of Interest

All authors contributed significantly to the study presented. All authors have read and approved the article. This manuscript has not been published in any language or has been submitted to any other journal at the same time. There are no conflicts of interest with regard to the authors. The authors declare that they have no competing financial interests.

Figures

Figure.
Figure.. Platelet receptors which mediate virus-platelet interaction and initiate intracellular signaling events.
HIV and DENV bind to CLEC-2 and DC-SIGN. DENV binds to GPIb and human CMV (hCMV) interacts with TLR2. Depending on the virus, HIV, HCV, DENV, IAV, EMCV and CVB3 can be detected depending on their genomic state as ssRNA, dsDNA or as dsRNA directly or as genomic intermediate during replication of ssRNA viruses by endosomal expressed TLRs. TLR7/8 detect ssRNA, TLR3 dsRNA and TLR9 dsDNA. Figure created in BioRender.com.
See this image and copyright information in PMC

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