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Comment
. 2021 Mar 1;49(3):e345-e346.
doi: 10.1097/CCM.0000000000004782.

Does Norepinephrine Exhibit a Time-Dose Relationship in Septic Shock?

Timothy W Jones  1 , Hanna Azimi  1 , Cambell Scott  1 , Andrea Sikora Newsome  1
Affiliations
Comment

Does Norepinephrine Exhibit a Time-Dose Relationship in Septic Shock?

Timothy W Jones et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

Dr. Newsome’s institution received funding from the National Institutes of Health (NIH), and she received support for article research from the NIH. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Comment in

  • The authors reply.
    Miano TA, Roberts RJ, Lat I. Miano TA, et al. Crit Care Med. 2021 Mar 1;49(3):e346-e347. doi: 10.1097/CCM.0000000000004870. Crit Care Med. 2021. PMID: 33616371 No abstract available.

Comment on

  • Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock.
    Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, Lopez N, Kashani K, Qadir N, Cairns CB, Mathews K, Park P, Khan A, Gilmore JF, Brown ART, Tsuei B, Handzel M, Chang AL, Duggal A, Lanspa M, Herbert JT, Martinez A, Tonna J, Ammar MA, Nazer LH, Heavner M, Pender E, Chambers L, Kenes MT, Kaufman D, Downey A, Brown B, Chaykosky D, Wolff A, Smith M, Nault K, Gong MN, Sevransky JE, Lat I; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network. Roberts RJ, et al. Crit Care Med. 2020 Oct;48(10):1445-1453. doi: 10.1097/CCM.0000000000004476. Crit Care Med. 2020. PMID: 32706559

References

    1. Roberts RJ, Miano TA, Hammond DA, et al.; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network: Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock. Crit Care Med 2020; 48:1445–1453 - PubMed
    1. Bai X, Yu W, Ji W, et al.: Early versus delayed administration of norepinephrine in patients with septic shock. Crit Care 2014; 18:532. - PMC - PubMed
    1. Permpikul C, Tongyoo S, Viarasilpa T, et al.: Early use of norepinephrine in septic shock resuscitation (CENSER). A randomized trial. Am J Respir Crit Care Med 2019; 199:1097–1105 - PubMed
    1. Colon Hidalgo D, Patel J, Masic D, et al.: Delayed vasopressor initiation is associated with increased mortality in patients with septic shock. J Crit Care 2020; 55:145–148 - PubMed
    1. Ospina-Tascón GA, Hernandez G, Alvarez I, et al.: Effects of very early start of norepinephrine in patients with septic shock: A propensity score-based analysis. Crit Care 2020; 24:52. - PMC - PubMed

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