The authors reply

Affiliations

¹ Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
² Department of Pharmacy, Massachusetts General Hospital, Boston, MA.
³ Department of Pharmacy, Shirley Ryan Abilitylab, Chicago, IL.

Comment

Todd A Miano et al. Crit Care Med. 2021.

. 2021 Mar 1;49(3):e346-e347.

doi: 10.1097/CCM.0000000000004870.

¹ Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
² Department of Pharmacy, Massachusetts General Hospital, Boston, MA.
³ Department of Pharmacy, Shirley Ryan Abilitylab, Chicago, IL.

No abstract available

Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock.
Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, Lopez N, Kashani K, Qadir N, Cairns CB, Mathews K, Park P, Khan A, Gilmore JF, Brown ART, Tsuei B, Handzel M, Chang AL, Duggal A, Lanspa M, Herbert JT, Martinez A, Tonna J, Ammar MA, Nazer LH, Heavner M, Pender E, Chambers L, Kenes MT, Kaufman D, Downey A, Brown B, Chaykosky D, Wolff A, Smith M, Nault K, Gong MN, Sevransky JE, Lat I; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network. Roberts RJ, et al. Crit Care Med. 2020 Oct;48(10):1445-1453. doi: 10.1097/CCM.0000000000004476. Crit Care Med. 2020. PMID: 32706559
Does Norepinephrine Exhibit a Time-Dose Relationship in Septic Shock?
Jones TW, Azimi H, Scott C, Newsome AS. Jones TW, et al. Crit Care Med. 2021 Mar 1;49(3):e345-e346. doi: 10.1097/CCM.0000000000004782. Crit Care Med. 2021. PMID: 33616370 Free PMC article. No abstract available.

1. Jones TW, Azimi H, Scott C, et al. Does Norepinephrine Exhibit a Time-Dose Relationship in Septic Shock? Crit Care Med. 2021; 49:e345–e346
1. Roberts RJ, Miano TA, Hammond DA, et al.; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network. Evaluation of vasopressor exposure and mortality in patients with septic shock. Crit Care Med. 2020; 48:1445–1453
1. Boerma EC, Ince C. The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med. 2010; 36:2004–2018
1. Ospina-Tascon G, Neves AP, Occhipinti G, et al. Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med. 2010; 36:949–955