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Randomized Controlled Trial
. 2021 Jun 1;175(6):631-632.
doi: 10.1001/jamapediatrics.2020.6150.

Rituximab vs Low-Dose Mycophenolate Mofetil in Recurrence of Steroid-Dependent Nephrotic Syndrome in Children and Young Adults: A Randomized Clinical Trial

Pietro Ravani  1 , Francesca Lugani  2 , Stefania Drovandi  2 , Gianluca Caridi  3 , Andrea Angeletti  2 , Gian Marco Ghiggeri  2
Affiliations
Randomized Controlled Trial

Rituximab vs Low-Dose Mycophenolate Mofetil in Recurrence of Steroid-Dependent Nephrotic Syndrome in Children and Young Adults: A Randomized Clinical Trial

Pietro Ravani et al. JAMA Pediatr. .

Abstract

This randomized clinical trial examines the superiority of a single dose of rituximab vs low-dose mycophenolate mofetil in preventing the recurrence of steroid-dependent nephrotic syndrome in children and young adults.

Trial registration: ClinicalTrials.gov NCT04402580.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Ghiggeri reported grants from Italian Ministry of Health No Profit grant (Ricerca Finalizzata PE-2016-02361576) during the conduct of the study. No other disclosures were reported

Figures

Figure 1.
Figure 1.. Schematic View of Trial Design
MMF indicates mycophenolate mofetil; PDN, prednisone.
Figure 2.
Figure 2.. One-Year Relapse-Free Survival in the Rituximab and Mycophenolate Mofetil (MMF) Arms
The risk of relapse was 0.8 (12/15) in the MMF and 0.13 (2/15; P = .008 in the rituximab arm, with higher odds in the MMF arm (odds ratio, 26; 95% CI, 2.9-311.0).
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References

    1. Ravani P, Rossi R, Bonanni A, et al. . Rituximab in children with steroid-dependent nephrotic syndrome: a multicenter, open-label, noninferiority, randomized controlled trial. J Am Soc Nephrol. 2015;26(9):2259-2266. doi:10.1681/ASN.2014080799 - DOI - PMC - PubMed
    1. Ravani P, Lugani F, Pisani I, et al. . Rituximab for very low dose steroid-dependent nephrotic syndrome in children: a randomized controlled study. Pediatr Nephrol. 2020;35(8):1437-1444. doi:10.1007/s00467-020-04540-4 - DOI - PubMed
    1. Gellermann J, Weber L, Pape L, Tönshoff B, Hoyer P, Querfeld U; Gesellschaft für Pädiatrische Nephrologie (GPN) . Mycophenolate mofetil versus cyclosporin A in children with frequently relapsing nephrotic syndrome. J Am Soc Nephrol. 2013;24(10):1689-1697. doi:10.1681/ASN.2012121200 - DOI - PMC - PubMed
    1. Novak I, Frank R, Vento S, Vergara M, Gauthier B, Trachtman H. Efficacy of mycophenolate mofetil in pediatric patients with steroid-dependent nephrotic syndrome. Pediatr Nephrol. 2005;20(9):1265-1268. doi:10.1007/s00467-005-1957-y - DOI - PubMed
    1. Moudgil A, Bagga A, Jordan SC. Mycophenolate mofetil therapy in frequently relapsing steroid-dependent and steroid-resistant nephrotic syndrome of childhood: current status and future directions. Pediatr Nephrol. 2005;20(10):1376-1381. doi:10.1007/s00467-005-1964-z - DOI - PubMed

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