Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug;40(8):1779-1785.
doi: 10.1007/s10096-021-04185-7. Epub 2021 Feb 22.

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid  1   2   3 , Clement K M Tsui  4   5   6 , Yohei Doi  7   8 , Anand Deshmukh  9 , Christi L McElheny  7 , William C Bachman  7 , Erin L Fowler  7 , Ahmed Albishawi  10   11 , Kamran Mushtaq  12 , Emad B Ibrahim  9 , Sanjay H Doiphode  9 , Manal M Hamed  9 , Muna A Almaslmani  10   11 , Abdullatif Alkhal  10   11 , Adeel A Butt  4   12 , Ali S Omrani  10   11   13
Affiliations

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid et al. Eur J Clin Microbiol Infect Dis. 2021 Aug.

Abstract

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

Keywords: CRE; Carbapenemase; Enterobacterales; KPC; Middle East; NDM; OXA; Qatar; VIM.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. van Duin D, Doi Y. The global epidemiology of carbapenemase-producing Enterobacteriaceae. Virulence. 2017;8:460–469. doi: 10.1080/21505594.2016.1222343. - DOI - PMC - PubMed
    1. Doi Y. Treatment options for carbapenem-resistant Gram-negative bacterial infections. Clin Infect Dis. 2019;69:S565–SS75. doi: 10.1093/cid/ciz830. - DOI - PMC - PubMed
    1. Palacios-Baena ZR, Giannella M, Manissero D et al (2020) Risk factors for carbapenem-resistant Gram-negative bacterial infections: a systematic review. Clin Microbiol Infect. 10.1016/j.cmi.2020.10.016 - PubMed
    1. Zilberberg MD, Nathanson BH, Sulham K, et al. Carbapenem resistance, inappropriate empiric treatment and outcomes among patients hospitalized with Enterobacteriaceae urinary tract infection, pneumonia and sepsis. BMC Infect Dis. 2017;17:279. doi: 10.1186/s12879-017-2383-z. - DOI - PMC - PubMed
    1. Boyd SE, Livermore DM, Hooper DC, et al. Metallo-beta-lactamases: structure, function, epidemiology, treatment options, and the development pipeline. Antimicrob Agents Chemother. 2020;64:e00397–e00320. doi: 10.1128/AAC.00397-20. - DOI - PMC - PubMed

MeSH terms

Substances