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. 2021 Apr 19;16(8):1007-1015.
doi: 10.1002/asia.202100053. Epub 2021 Mar 22.

A New Potent Antimicrobial Metalloporphyrin

Lu Jiang  1 , Pei Lin Chee  1 , Jian Gao  2 , Ching Ruey Raymond Gan  2 , Cally Owh  1 , Rajamani Lakshminarayanan  3   4   5 , Shan Jiang  6 , T S Andy Hor  2   7 , Xian Jun Loh  1   8
Affiliations

A New Potent Antimicrobial Metalloporphyrin

Lu Jiang et al. Chem Asian J. .

Abstract

A series of bis-acryl functionalized porphyrins and their corresponding metalloporphyrins (M=Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time-kill kinetic studies. The Mn(III) 4-(bis)methylphenyl-substituted-porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile.

Keywords: antimicrobial agents; metalloporphyrins; organometallic; porphyrin.

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References

    1. None
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    1. None
    1. Center for Disease Control and Prevention (CDC), Atlanta, GA, USA, 2013;

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