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Meta-Analysis
. 2021 Sep;8(5):2249-2261.
doi: 10.1002/nop2.811. Epub 2021 Feb 22.

The incidence of asymptomatic thrombosis related to peripherally inserted central catheter in adults: A systematic review and meta-analysis People's

Pei Chen  1 , Bingqian Zhu  1 , Guangming Wan  2 , Liyuan Qin  1
Affiliations
Meta-Analysis

The incidence of asymptomatic thrombosis related to peripherally inserted central catheter in adults: A systematic review and meta-analysis People's

Pei Chen et al. Nurs Open. 2021 Sep.

Abstract

Aim: To examine the incidence and risk factors for asymptomatic peripherally inserted central catheter-related thrombosis (PICC-RT).

Design: We performed a systematic review and meta-analysis following the PRISMA guidelines.

Methods: The review was registered in PROSPERO (CRD42020186732). A systematic search of EMBASE, CINAHL, PubMed, Web of Science and Cochrane was performed from inception to 4 June 2020. Meta-analysis was performed to determine the pooled incidence of asymptomatic PICC-RT.

Results: Ten studies comprising 1591 participants with 1592 PICCs were included in this meta-analysis. The pooled incidence of asymptomatic PICC-RT in adults was 22% (95% CI, 0.17-0.29). The pooled incidence of PICC-RT in cancer patients was 19% (95% CI, 0.13-0.26). Asymptomatic PICC-RT mainly occurred in superficial veins. Most asymptomatic thrombosis occurred 3-12 days after the PICC insertion. A higher Eastern Cooperative Oncology Group score (ECOG), slower blood flow velocity and left basilic vein were independent risk factors of asymptomatic thrombosis.

Keywords: asymptomatic; incidence; peripherally inserted central catheter; thrombosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
PRISMA flowchart for study selection
FIGURE 2
FIGURE 2
Forest plots for 10 studies assessing the incidence of asymptomatic PICC‐RT: subgroup analysis based on whether cancer patients or not. Notes. NCP, non‐cancer patients: OR = 0.39, p =.002; CP, cancer patients: OR = 0.24, p =.000; Overall: OR = 0.29. p =.000
FIGURE 3
FIGURE 3
Forest plots for 10 studies assessing the incidence of asymptomatic PICC‐RT: subgroup analysis based on study design. Notes. RCT, randomized controlled trial: OR = 0.24, p =.000; PS, prospective study: OR = 0.30, p =.004; Overall: OR = 0.29.p =.000
FIGURE 4
FIGURE 4
Funnel plot assessing the heterogeneity of the 10 studies on incidence of asymptomatic PICC‐RT
FIGURE 5
FIGURE 5
Egger assessing the heterogeneity of the 10 studies on incidence of asymptomatic PICC‐RT. p =.073, 95% CI (−8.61 to 0.47)
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