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Clinical Trial
. 1977 Nov;40(5):2091-3.
doi: 10.1002/1097-0142(197711)40:5<2091::aid-cncr2820400517>3.0.co;2-h.

A Phase II study of autologous irradiated tumor cells plus BCG in patients with metastatic malignant melanoma

J F Laucius, A J Bodurtha, J M Mastrangelo, R E Bellet
Clinical Trial

A Phase II study of autologous irradiated tumor cells plus BCG in patients with metastatic malignant melanoma

J F Laucius et al. Cancer. 1977 Nov.

Abstract

Eighteen patients with surgically incurable metastatic malignant melanoma were treated with a mixture of irradiated (15,000 rads) autologous tumors cells (1-2 X 10(8)) and BCG (Glaxo, 2-4.5 X 10(6) organisms), which was injected intradermally (in five divided doses) every 2 weeks (X5). Four of 18 (22%) evaluable patients achieved objective remissions. It is concluded that this treatment regimen does not have general clinical application because the remissions were infrequent, of shor duration (median, 3 months) and occurred only in patients with minimal, nonvisceral tumor burdens.

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