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Meta-Analysis
. 2021 Jan 13;32(3):351-361.
doi: 10.1515/revneuro-2020-0108. Print 2021 Apr 27.

COVID-19 associated central nervous system manifestations, mental and neurological symptoms: a systematic review and meta-analysis

Saber Soltani  1   2 , Alireza Tabibzadeh  3 , Armin Zakeri  4 , Amir Mohammad Zakeri  5 , Tayebeh Latifi  1 , Mahdi Shabani  1 , Amir Pouremamali  6 , Yousef Erfani  7 , Iraj Pakzad  8 , Pooneh Malekifar  9 , Reza Valizadeh  10 , Milad Zandi  1   11 , Reza Pakzad  12   13
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Free article
Meta-Analysis

COVID-19 associated central nervous system manifestations, mental and neurological symptoms: a systematic review and meta-analysis

Saber Soltani et al. Rev Neurosci. .
Free article

Abstract

The ongoing pandemic of Coronavirus disease 2019 (COVID-19) has infected more than 27 million confirmed cases and 8,90,000 deaths all around the world. Verity of viral infections can infect the nervous system; these viral infections can present a wide range of manifestation. The aim of the current study was to systematically review the COVID-19 associated central nervous system manifestations, mental and neurological symptoms. For that we conducted a comprehensive systematic literature review of four online databases, including Web of Science, PubMed, Scopus and Embase. All relevant articles that reported psychiatric/psychological symptoms or disorders in COVID-19 without considering time and language restrictions were assessed. All the study procedures were performed based on the PRISMA criteria. Due to the screening, 14 studies were included. The current study result indicated that, the pooled prevalence of CNS or mental associated disorders with 95% CI was 50.68% (6.68-93.88). The most prevalence symptoms were hyposmia/anosmia/olfactory dysfunction (number of study: 10) with 36.20% (14.99-60.51). Only one study reported numbness/paresthesia and dysphonia. Pooled prevalence of numbness/paresthesia and dysphonia was 5.83% (2.17-12.25) and 2.39% (10.75-14.22). The pooled prevalence of depression and anxiety was 3.52% (2.62-4.54) and 13.92% (9.44-19.08). Our findings demonstrate that COVID-19 has a certain relation with neurological symptoms. The hypsomia, anosmia or olfactory dysfunction was most frequent symptom. Other symptoms were headache or dizziness, dysgeusia or ageusia, dysphonia and fatigue. Depression, anxiety, and confusion were less frequent symptoms.

Keywords: COVID-19; SARS-CoV-2; central nervous system; neurological symptoms; psychiatric symptoms.

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References

    1. Abiodun, O. and Ola, M. (2020). Role of brain renin angiotensin system in neurodegeneration: an update. Saudi J. Biol. Sci. 27: 905–912.
    1. Aggarwal, S., Garcia-Telles, N., Aggarwal, G., Lavie, C., Lippi, G., and Henry, B.M. (2020). Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): early report from the United States. Diagnosis 7: 91–96.
    1. Al-Hameed, F. (2017). Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus. Saudi Med. J. 38: 196–200.
    1. Al-Obaidi, M., Bahadoran, A., Wang, S., Manikam, R., Raju, C., and Sekaran, S. (2018). Disruption of the blood brain barrier is vital property of neurotropic viral infection of the central nervous system. Acta Virol. 62: 16–27.
    1. Al-Samkari, H. and Berliner, N. (2018). Hemophagocytic lymphohistiocytosis. Annu. Rev. Pathol. 13: 27–49.

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