Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations: A Preclinical Study

Affiliations

¹ Department of Immunology, Genetics and Pathology (J.O., M.A.G., L.L.C., C.R., V.S., M.A., R.O.S., A.C.Y.Y., E.D., P.U.M.), Uppsala University, Sweden.
² Vascular Biology Unit (M.M., C.M., M.C., F.O., G.V.B., M.G.L., E.D.), The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
³ Department of Surgical Sciences, Orthopaedics (G.H.B.), Uppsala University, Sweden.
⁴ Department of Materials and Science and Engineering, Applied Materials Science (C.O.M.), Uppsala University, Sweden.
⁵ Electron Microscopic Laboratory (G.V.B., A.A.M.), The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
⁶ Department of Biomaterials and Technology/Wood Science, Swedish University of Agricultural Sciences, Uppsala (D.F., G.D.).
⁷ Cardiopulmonary Physiopathology Laboratory, Cardiovascular Medicine Department, Instituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy (D.O., F.F.).
⁸ Mario Negri Institute for Pharmacological Research, Milan, Italy (M.G.L.).
⁹ Department of Oncology and Haemato-Oncology, School of Medicine, University of Milan, Italy (E.D.).

Joppe Oldenburg et al. Stroke. 2021 Apr.

. 2021 Apr;52(4):1418-1427.

doi: 10.1161/STROKEAHA.120.029676. Epub 2021 Feb 23.

¹ Department of Immunology, Genetics and Pathology (J.O., M.A.G., L.L.C., C.R., V.S., M.A., R.O.S., A.C.Y.Y., E.D., P.U.M.), Uppsala University, Sweden.
² Vascular Biology Unit (M.M., C.M., M.C., F.O., G.V.B., M.G.L., E.D.), The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
³ Department of Surgical Sciences, Orthopaedics (G.H.B.), Uppsala University, Sweden.
⁴ Department of Materials and Science and Engineering, Applied Materials Science (C.O.M.), Uppsala University, Sweden.
⁵ Electron Microscopic Laboratory (G.V.B., A.A.M.), The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
⁶ Department of Biomaterials and Technology/Wood Science, Swedish University of Agricultural Sciences, Uppsala (D.F., G.D.).
⁷ Cardiopulmonary Physiopathology Laboratory, Cardiovascular Medicine Department, Instituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy (D.O., F.F.).
⁸ Mario Negri Institute for Pharmacological Research, Milan, Italy (M.G.L.).
⁹ Department of Oncology and Haemato-Oncology, School of Medicine, University of Milan, Italy (E.D.).

Abstract

[Figure: see text].

Keywords: cavernous; central nervous system; endothelial cells; pericytes; propranolol; vascular malformations.