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Review
. 2021 Apr;56(2):178-204.
doi: 10.1080/10409238.2021.1887807. Epub 2021 Feb 22.

Instrumental analysis of RNA modifications

Yasemin Yoluç  1 , Gregor Ammann  1 , Pierre Barraud  2 , Manasses Jora  3 , Patrick A Limbach  3 , Yuri Motorin  4 , Virginie Marchand  5 , Carine Tisné  2 , Kayla Borland  1 , Stefanie Kellner  1   6
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Free article
Review

Instrumental analysis of RNA modifications

Yasemin Yoluç et al. Crit Rev Biochem Mol Biol. 2021 Apr.
Free article

Abstract

Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks. Here, we will review recent advances and breakthroughs achieved by NMR spectroscopy, sequencing, and mass spectrometry of the epitranscriptome.

Keywords: E; pitranscriptome.

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