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. 2021 Feb 22;11(1):4337.
doi: 10.1038/s41598-021-83502-8.

The incidence and clinical analysis of non-melanoma skin cancer

Magdalena Ciążyńska  1 , Grażyna Kamińska-Winciorek  2 , Dariusz Lange  3 , Bogumił Lewandowski  4 , Adam Reich  5 , Martyna Sławińska  6 , Marta Pabianek  7 , Katarzyna Szczepaniak  7 , Adam Hankiewicz  7 , Małgorzata Ułańska  7 , Jan Morawiec  8 , Maria Błasińska-Morawiec  7 , Zbigniew Morawiec  8 , Janusz Piekarski  9 , Dariusz Nejc  9 , Robert Brodowski  4 , Anna Zaryczańska  6 , Michał Sobjanek  6 , Roman J Nowicki  6 , Witold Owczarek  10 , Monika Słowińska  10 , Katarzyna Wróbel  10 , Andrzej Bieniek  11 , Anna Woźniacka  12 , Małgorzata Skibińska  13 , Joanna Narbutt  13 , Wojciech Niemczyk  14 , Karol Ciążyński  15 , Aleksandra Lesiak  13
Affiliations

The incidence and clinical analysis of non-melanoma skin cancer

Magdalena Ciążyńska et al. Sci Rep. .

Erratum in

  • Author Correction: The incidence and clinical analysis of non‑melanoma skin cancer.
    Ciążyńska M, Kamińska-Winciorek G, Lange D, Lewandowski B, Reich A, Sławińska M, Pabianek M, Szczepaniak K, Hankiewicz A, Ułańska M, Morawiec J, Błasińska-Morawiec M, Morawiec Z, Piekarski J, Nejc D, Brodowski R, Zaryczańska A, Sobjanek M, Nowicki RJ, Owczarek W, Słowińska M, Wróbel K, Bieniek A, Woźniacka A, Skibińska M, Narbutt J, Niemczyk W, Ciążyński K, Lesiak A. Ciążyńska M, et al. Sci Rep. 2021 Jul 28;11(1):15705. doi: 10.1038/s41598-021-94435-7. Sci Rep. 2021. PMID: 34321505 Free PMC article. No abstract available.

Abstract

Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. Retrospective analysis of BCCs and SCCs diagnosed and treated across seven sites in Poland from 1999 to 2019. We recorded 13,913 NMSCs occurring in 10,083 patients. BCC represented 85.2% of all cases. SCC patients were older than BCC patients (77.1 ± 11.3 years vs. 70.1 ± 12.3 years, p < 0.01). The nodular subtype was the most common subtype of BCC, followed by the superficial and infiltrative subtypes. The superficial BCC subtype was more common on photoprotected areas (p < 0.01), whereas the nodular BCC subtype occurred on the face (p < 0.01). The high-risk SCC subtypes were more common on face compared to low-risk SCC subtypes (p < 0.01). BCC and SCC are common malignancies developing at various ages and anatomical sites. These data underline the need for better registration policies regarding NMSC in order to improve prevention and treatment strategies for these tumours.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Incidence of cases diagnosed using ICD-10 code C44 between 1999 and 2019 according to the Polish National Health Fund per 100,000 person-years. ICD-10: International Classification of Diseases, 11th Revision.
Figure 2
Figure 2
Annual BCC to SCC ratio between 1999 and 2019.
Figure 3
Figure 3
Male and female incidence rate for NMSC relation between 1999 and 2019.
Figure 4
Figure 4
Age-specific incidence rates for NMSC (n = 13,913). SCC patients were significantly older than BCC patients (p < 0.01). NMSC non-melanoma skin cancer, SCC squamous cell carcinoma; BCC basal cell carcinoma.
Figure 5
Figure 5
Age-specific incidence rates for NMSC in relation to sex; n = 13,913. In patients 18–44 years old, there was a significant predominance of women (p < 0.01). In patients 45–69 years old, there was no predominance in sex (p = 0.93). In patients 70–79 years old, there was a significant predominance of men (p < 0.01). In patients 80–102 years old, there was a significant predominance of women (p < 0.01).
Figure 6
Figure 6
Age-specific incidence rates for NMSC between 1999 and 2019.
Figure 7
Figure 7
Distribution of BCC subtypes between 1999 and 2019.
See this image and copyright information in PMC

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